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v3.7.0.1

Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2017 | Mar. 31, 2016
Operating activities |  |
Net loss | $ (14,219,000) | $ (22,832,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 172,000 | 47,000
Stock-based compensation expense | 2,462,000 | 2,645,000
Amortization of Debt Issuance Costs | 220,000 | 110,000
Amortization of premium/discount on investments | 18,000 | 233,000
Change in fair value of foreign currency derivative | 1,543,000 | 2,753,000
Changes in operating assets and liabilities: |  |
Receivables | (796,000) | (1,141,000)
Inventory | (155,000) | (337,000)
Prepaid expenses and other assets | (284,000) | (546,000)
Deferred collaboration expense | 18,000 | 19,000
Accounts payable and accrued expenses | 1,642,000 | (541,000)
Interest payable | 1,301,000 | 1,228,000
Deferred revenue | (449,000) | (480,000)
Net cash used in operating activities | (8,527,000) | (18,842,000)
Investing activities |  |
Acquisitions of property and equipment | (3,000) | (3,260,000)
Change in restricted cash | (1,252,000) | (353,000)
Sales and maturities of investments | 14,136,000 | 6,320,000
Net cash provided by investing activities | 12,881,000 | 2,707,000
Financing activities |  |
Sale of common stock, net | 47,750,000 |
Net proceeds from common stock issued under stock-based compensation plans | 950,000 | 7,000
Increase in lease financing obligation |  | 131,000
Net cash provided by financing activities | 48,700,000 | 138,000
Increase (decrease) in cash and cash equivalents | 53,054,000 | (15,997,000)
Cash and cash equivalents at beginning of period | 22,104,000 | 28,899,000
Cash and cash equivalents at end of period | $ 75,158,000 | $ 12,902,000

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