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Note 1 - Significant Accounting Policies (Tables) | 3 Months Ended
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Mar. 31, 2017
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | March 31, 2017
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 7,312 |  |  | $ | 27 |  |  | $ | — |  |  | $ | (5 | ) |  | $ | 7,334 |
Corporate debt securities |  |  | 6,171 |  |  |  | 21 |  |  |  | — |  |  |  | (4 | ) |  |  | 6,188 |
Certificates of deposit |  |  | 13,775 |  |  |  | 24 |  |  |  | 11 |  |  |  | (5 | ) |  |  | 13,805 |
Total investments |  | $ | 27,258 |  |  | $ | 72 |  |  | $ | 11 |  |  | $ | (14 | ) |  | $ | 27,327 |
|  | December 31, 2016
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 20,266 |  |  | $ | 34 |  |  | $ | 2 |  |  | $ | (4 | ) |  | $ | 20,298 |
Corporate debt securities |  |  | 6,179 |  |  |  | 26 |  |  |  | 2 |  |  |  | (8 | ) |  |  | 6,199 |
Certificates of deposit |  |  | 14,962 |  |  |  | 17 |  |  |  | 7 |  |  |  | (11 | ) |  |  | 14,975 |
Total investments |  | $ | 41,407 |  |  | $ | 77 |  |  | $ | 11 |  |  | $ | (23 | ) |  | $ | 41,472 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | 2017 |  | 2016
Maturing in one year or less |  | $ | 23,524 |  |  | $ | 32,546 |
Maturing after one year through two years |  |  | 3,803 |  |  |  | 8,926 |
Total investments |  | $ | 27,327 |  |  | $ | 41,472 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | March 31, 2017
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 114 |  |  | $ | 2,186 |  |  | $ | 2,300 |
Shionogi & Co. Ltd. |  |  | 5,834 |  |  |  | — |  |  |  | 5,834 |
Green Cross Corporation |  |  | 382 |  |  |  | — |  |  |  | 382 |
Seqirus UK Limited |  |  | 891 |  |  |  | 157 |  |  |  | 1,048 |
Total receivables |  | $ | 7,221 |  |  | $ | 2,343 |  |  | $ | 9,564 |
|  | December 31, 2016
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 3,495 |  |  | $ | 3,495 |
Shionogi & Co. Ltd. |  |  | 3,451 |  |  |  | — |  |  |  | 3,451 |
Green Cross Corporation |  |  | 686 |  |  |  | — |  |  |  | 686 |
Seqirus UK Limited |  |  | 957 |  |  |  | 179 |  |  |  | 1,136 |
Total receivables |  | $ | 5,094 |  |  | $ | 3,674 |  |  | $ | 8,768 |
Schedule of Inventory, Current [Table Text Block] |
|  | 2017 |  | 2016
Work in process |  | $ | 655 |  |  | $ | 500 |
Inventories |  | $ | 655 |  |  | $ | 500 |
Schedule of Revenues from Collaborations [Table Text Block] |
|  | 2017 |  | 2016
Royalty revenue |  | $ | 6,321 |  |  | $ | 1,890 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 654 |  |  |  | 2,324 |
Shionogi & Co., Ltd. |  |  | 296 |  |  |  | 296 |
Seqirus UK Limited |  |  | 2,166 |  |  |  | 310 |
Total collaborative and other research and development revenues |  |  | 3,116 |  |  |  | 2,930 |
Total revenues |  | $ | 9,437 |  |  | $ | 4,820 |

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