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Note 1 - Significant Accounting Policies (Tables)
 3 Months Ended
Mar. 31, 2017
Notes Tables  
Available-for-sale Securities [Table Text Block]
    March 31, 2017
    Amortized
Cost		   Accrued
Interest		   Gross
Unrealized
Gains		   Gross
Unrealized
Losses		   Estimated
Fair Value
Obligations of the U.S. Government and its agencies   $
7,312
     $
27
     $
—
     $
(5
 )   $
7,334
  
Corporate debt securities    
6,171
      
21
      
—
      
(4
 )    
6,188
  
Certificates of deposit    
13,775
      
24
      
11
      
(5
 )    
13,805
  
                                         
Total investments   $
27,258
     $
72
     $
11
     $
(14
 )   $
27,327
  
    December 31, 2016
    Amortized
Cost		   Accrued
Interest		   Gross
Unrealized
Gains		   Gross
Unrealized
Losses		   Estimated
Fair Value
Obligations of the U.S. Government and its agencies   $
20,266
     $
34
     $
2
     $
(4
 )   $
20,298
  
Corporate debt securities    
6,179
      
26
      
2
      
(8
 )    
6,199
  
Certificates of deposit    
14,962
      
17
      
7
      
(11
 )    
14,975
  
                                         
Total investments   $
41,407
     $
77
     $
11
     $
(23
 )   $
41,472
  
Available For Sale Securities Debt Maturities Fair Value [Table Text Block]
    2017   2016
Maturing in one year or less   $
23,524
     $
32,546
  
Maturing after one year through two years    
3,803
      
8,926
  
                 
Total investments   $
27,327
     $
41,472
  
Schedule of Receivables from Collaborations [Table Text Block]
    March 31, 2017
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $
114
     $
2,186
     $
2,300
  
Shionogi & Co. Ltd.    
5,834
      
—
      
5,834
  
Green Cross Corporation    
382
      
—
      
382
  
Seqirus UK Limited    
891
      
157
      
1,048
  
                         
Total receivables   $
7,221
     $
2,343
     $
9,564
  
    December 31, 2016
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $
—
     $
3,495
     $
3,495
  
Shionogi & Co. Ltd.    
3,451
      
—
      
3,451
  
Green Cross Corporation    
686
      
—
      
686
  
Seqirus UK Limited    
957
      
179
      
1,136
  
                         
Total receivables   $
5,094
     $
3,674
     $
8,768
  
Schedule of Inventory, Current [Table Text Block]
    2017   2016
Work in process   $
655
     $
500
  
                 
Inventories   $
655
     $
500
  
Schedule of Revenues from Collaborations [Table Text Block]
    2017   2016
Royalty revenue   $
6,321
     $
1,890
  
Collaborative and other research and development revenues:                
U.S. Department of Health and Human Services    
654
      
2,324
  
Shionogi & Co., Ltd.    
296
      
296
  
Seqirus UK Limited    
2,166
      
310
  
Total collaborative and other research and development revenues    
3,116
      
2,930
  
                 
Total revenues   $
9,437
     $
4,820