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Note 2 - Stock-based Compensation (Details Textual) $ / shares in Units, shares in Thousands, $ in Thousands | 1 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Aug. 31, 2013 shares | Jun. 30, 2017 USD ($) $ / shares shares | Jun. 30, 2016 USD ($) $ / shares | Dec. 31, 2014 shares | Dec. 31, 2016 shares
Number of Stock-based Compensation Plans |  | 2 |  |  |
Allocated Share-based Compensation Expense |  | $ 4,788 | $ 4,491 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized |  | 18,575 |  |  |
Employee Service Share-based Compensation Nonvested Awards Compensation Cost Expected to be Recognized For Remainder of Fiscal Year |  | 4,555 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Two |  | 6,768 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Three |  | 4,525 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Four |  | 2,387 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Five |  | 340 |  |  |
Incentive Plan [Member] |  |  |  |  |
Allocated Share-based Compensation Expense |  | $ 4,652 | $ 4,402 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares |  | $ 3.74 | $ 2.18 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  | 0.00% | 0.00% |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | shares |  | 1,578 |  |  | 2,273
Incentive Plan [Member] | Employee Stock Option [Member] |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  | 0.00% |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Minimum [Member] |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  | 5 years |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Maximum [Member] |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  | 10 years |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Non-employee Directors [Member] |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, First Vesting Period After Grant Date |  | 1 year |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Vest 25% Each Year Until Fully Vested [Member] |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  | 4 years |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  | 25.00% |  |  |
Incentive Plan [Member] | Performance Shares [Member] |  |  |  |  |
Allocated Share-based Compensation Expense |  | $ 0 |  |  |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | shares | 1,032 |  |  | 1,250 |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | August 2013 [Member] |  |  |  |  |
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage |  | 25.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  | 75.00% |  |  |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | December 2014 [Member] |  |  |  |  |
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage |  | 100.00% |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |
Allocated Share-based Compensation Expense |  | $ 136 | $ 89 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized | shares |  | 1,475 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | shares |  | 364 |  |  |
Percentage of Salary to Purchase Common Stock, Maximum |  | 15.00% |  |  |
Percentage of Common Stock Shares, Beginning |  | 85.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee | shares |  | 3 |  |  |
Shar-based Compensation Arrangement by Shar-based Payment Award, Maximum Number of Shares Per Employee, Amount |  | $ 25 |  |  |
Stock Issued During Period, Shares, Employee Stock Purchase Plans | shares |  | 58 |  |  |

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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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