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v3.7.0.1

Note 1 - Significant Accounting Policies (Details Textual) - USD ($) shares in Thousands, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jun. 30, 2015 | Jun. 30, 2017 | Jun. 30, 2016 | Jun. 30, 2017 | Jun. 30, 2016 | Dec. 31, 2016 | Sep. 23, 2016 | Dec. 31, 2015 | Mar. 09, 2011
Revenues |  | $ 3,099 | $ 4,787 | $ 12,536 | $ 9,607 |  |  |  |
Interest Expense, Debt |  | 2,094 | 1,421 | 4,194 | 2,891 |  |  |  |
Amortization of Debt Issuance Costs |  | 220 | 110 | 439 | 220 |  |  |  |
Long-term Line of Credit |  | 19,999 |  | 19,999 |  | $ 22,777 |  |  |
Restricted Cash and Cash Equivalents, Current |  | 5,357 |  | 5,357 |  | 1,546 |  |  |
Loss on Sale of Investments |  |  |  | 0 |  |  |  |  |
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax |  |  |  | (1) | 10 |  |  |  |
Interest Expense |  | $ 2,094 | $ 1,421 | $ 4,194 | $ 2,891 |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  | 2,208 | 885 | 2,475 | 1,091 |  |  |  |
Lease Financing Obligation, Net of Current |  | $ 2,704 |  | $ 2,704 |  | 2,704 |  |  |
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |  |  |  |  |  |
Derivative, Gain on Derivative |  |  |  | 921 | $ 811 |  |  |  |
Derivative, Loss on Derivative |  |  |  | 1,943 | 6,441 |  |  |  |
Currency Hedge Agreement [Member] |  |  |  |  |  |  |  |  |
Collateral Already Posted, Aggregate Fair Value |  | 0 |  | 0 |  | 0 |  |  |
Birmingham Research Facility [Member] |  |  |  |  |  |  |  |  |
Interest Expense |  | 55 | $ 83 | 135 | $ 214 |  |  |  |
Lease Financing Obligation, Net of Current |  | 2,704 |  | 2,704 |  | $ 2,704 |  |  |
Capital Leases, Future Minimum Payments Due |  | 4,553 |  | $ 4,553 |  |  |  |  |
Agreement [Member] | CSL [Member] | RAPIVAB [Member] |  |  |  |  |  |  |  |  |
Proceeds from License Fees Received | $ 33,740 |  |  |  |  |  |  |  |
Revenues | 21,777 |  |  |  |  |  |  |  |
Milestone Payment Maximum | 10,000 |  |  |  |  |  |  |  |
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member] |  |  |  |  |  |  |  |  |
Deferred Revenue, Additions | 3,740 |  |  |  |  |  |  |  |
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member] |  |  |  |  |  |  |  |  |
Deferred Revenue, Additions | 1,223 |  |  |  |  |  |  |  |
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Contingent upon EU Marketing Approval [Member] |  |  |  |  |  |  |  |  |
Proceeds from License Fees Received | $ 7,000 |  |  |  |  |  |  |  |
Computer Equipment [Member] |  |  |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  |  | 3 years |  |  |  |  |
Laboratory Equipment, Office Equipment and Software [Member] |  |  |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  |  | 5 years |  |  |  |  |
Furniture and Fixtures [Member] |  |  |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  |  | 7 years |  |  |  |  |
Leasehold Improvements [Member] | Birmingham Research Facility [Member] |  |  |  |  |  |  |  |  |
Property, Plant and Equipment, Gross |  |  |  |  |  |  |  | $ 1,589 |
Property, Plant and Equipment, Useful Life |  |  |  | 20 years 182 days |  |  |  |  |
Maximum [Member] |  |  |  |  |  |  |  |  |
Maturity Period of High Quality Marketable Securities |  |  |  | 3 years |  |  |  |  |
Average Maturity Period of High Quality Marketable Securities |  |  |  | 1 year 180 days |  |  |  |  |
Maturity Period of Short Term Investment |  |  |  | 1 year |  |  |  |  |
Average Maturity for Portfolio Investments |  |  |  | 1 year 180 days |  |  |  |  |
Minimum [Member] |  |  |  |  |  |  |  |  |
Long-term Investment Maturity, Minimum |  |  |  | 1 year |  |  |  |  |
Royalty Receivable [Member] |  |  |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current |  | 3,949 |  | $ 3,949 |  |  |  |  |
Collateral for Credit [Member] |  |  |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current |  | 1,408 |  | 1,408 |  |  |  |  |
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member] |  |  |  |  |  |  |  |  |
Long-term Line of Credit |  | $ 23,000 |  | $ 23,000 |  |  | $ 23,000 |  |
JPR Royalty Sub LLC [Member] |  |  |  |  |  |  |  |  |
Revenue Recognition Royalty and Milestone Revenue Recognized |  |  |  |  |  |  |  |  | $ 30,000

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