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Note 1 - Significant Accounting Policies (Tables)
 6 Months Ended
Jun. 30, 2017
Notes Tables  
Available-for-sale Securities [Table Text Block]
    June 30, 2017
    Amortized
Cost		   Accrued
Interest		   Gross
Unrealized
Gains		   Gross
Unrealized
Losses		   Estimated
Fair Value
Obligations of the U.S. Government and its agencies   $
26,436
     $
85
     $
—
     $
(11
 )   $
26,510
  
Corporate debt securities    
9,248
      
42
      
1
      
(8
 )    
9,283
  
Certificates of deposit    
14,762
      
22
      
9
      
(6
 )    
14,787
  
                                         
Total investments   $
50,446
     $
149
     $
10
     $
(25
 )   $
50,580
  
    December 31, 2016
    Amortized
Cost		   Accrued
Interest		   Gross
Unrealized
Gains		   Gross
Unrealized
Losses		   Estimated
Fair Value
Obligations of the U.S. Government and its agencies   $
20,266
     $
34
     $
2
     $
(4
 )   $
20,298
  
Corporate debt securities    
6,179
      
26
      
2
      
(8
 )    
6,199
  
Certificates of deposit    
14,962
      
17
      
7
      
(11
 )    
14,975
  
                                         
Total investments   $
41,407
     $
77
     $
11
     $
(23
 )   $
41,472
  
Available For Sale Securities Debt Maturities Fair Value [Table Text Block]
    2017   2016
Maturing in one year or less   $
40,977
     $
32,546
  
Maturing after one year through two years    
9,603
      
8,926
  
                 
Total investments   $
50,580
     $
41,472
  
Schedule of Receivables from Collaborations [Table Text Block]
    June 30, 2017
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $
276
     $
1,630
     $
1,906
  
Shionogi & Co. Ltd.    
107
      
—
      
107
  
Green Cross Corporation    
359
      
—
      
359
  
Seqirus UK Limited    
747
      
206
      
953
  
                         
Total receivables   $
1,489
     $
1,836
     $
3,325
  
    December 31, 2016
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $
—
     $
3,495
     $
3,495
  
Shionogi & Co. Ltd.    
3,451
      
—
      
3,451
  
Green Cross Corporation    
686
      
—
      
686
  
Seqirus UK Limited    
957
      
179
      
1,136
  
                         
Total receivables   $
5,094
     $
3,674
     $
8,768
  
Schedule of Inventory, Current [Table Text Block]
    2017   2016
Work in process   $
1,305
     $
500
  
                 
Inventories   $
1,305
     $
500
  
Schedule of Revenues from Collaborations [Table Text Block]
    Three Months   Six Months
    2017   2016   2017   2016
Royalty revenue   $
489
     $
629
     $
6,810
     $
2,519
  
Collaborative and other research and development revenues:                                
U.S. Department of Health and Human Services    
2,161
      
3,709
      
2,815
      
6,033
  
Shionogi & Co. Ltd.    
296
      
296
      
592
      
592
  
Seqirus UK Limited    
153
      
153
      
2,319
      
463
  
Total collaborative and other research and development revenues    
2,610
      
4,158
      
5,726
      
7,088
  
                                 
Total revenues   $
3,099
     $
4,787
     $
12,536
     $
9,607