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Note 1 - Significant Accounting Policies (Details Textual) - USD ($)
shares in Thousands, $ in Thousands
 1 Months Ended 3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Sep. 23, 2016
Dec. 31, 2015
Mar. 09, 2011
Revenues   $ 3,099 $ 4,787 $ 12,536 $ 9,607        
Interest Expense, Debt   2,094 1,421 4,194 2,891        
Amortization of Debt Issuance Costs   220 110 439 220        
Long-term Line of Credit   19,999   19,999   $ 22,777      
Restricted Cash and Cash Equivalents, Current   5,357   5,357   1,546      
Loss on Sale of Investments       0          
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax       (1) 10        
Interest Expense   $ 2,094 $ 1,421 $ 4,194 $ 2,891        
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount   2,208 885 2,475 1,091        
Lease Financing Obligation, Net of Current   $ 2,704   $ 2,704   2,704      
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]                  
Derivative, Gain on Derivative       921 $ 811        
Derivative, Loss on Derivative       1,943 6,441        
Currency Hedge Agreement [Member]                  
Collateral Already Posted, Aggregate Fair Value   0   0   0      
Birmingham Research Facility [Member]                  
Interest Expense   55 $ 83 135 $ 214        
Lease Financing Obligation, Net of Current   2,704   2,704   $ 2,704      
Capital Leases, Future Minimum Payments Due   4,553   $ 4,553          
Agreement [Member] | CSL [Member] | RAPIVAB [Member]                  
Proceeds from License Fees Received $ 33,740                
Revenues 21,777                
Milestone Payment Maximum 10,000                
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member]                  
Deferred Revenue, Additions 3,740                
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]                  
Deferred Revenue, Additions 1,223                
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Contingent upon EU Marketing Approval [Member]                  
Proceeds from License Fees Received $ 7,000                
Computer Equipment [Member]                  
Property, Plant and Equipment, Useful Life       3 years          
Laboratory Equipment, Office Equipment and Software [Member]                  
Property, Plant and Equipment, Useful Life       5 years          
Furniture and Fixtures [Member]                  
Property, Plant and Equipment, Useful Life       7 years          
Leasehold Improvements [Member] | Birmingham Research Facility [Member]                  
Property, Plant and Equipment, Gross               $ 1,589  
Property, Plant and Equipment, Useful Life       20 years 182 days          
Maximum [Member]                  
Maturity Period of High Quality Marketable Securities       3 years          
Average Maturity Period of High Quality Marketable Securities       1 year 180 days          
Maturity Period of Short Term Investment       1 year          
Average Maturity for Portfolio Investments       1 year 180 days          
Minimum [Member]                  
Long-term Investment Maturity, Minimum       1 year          
Royalty Receivable [Member]                  
Restricted Cash and Cash Equivalents, Current   3,949   $ 3,949          
Collateral for Credit [Member]                  
Restricted Cash and Cash Equivalents, Current   1,408   1,408          
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]                  
Long-term Line of Credit   $ 23,000   $ 23,000     $ 23,000    
JPR Royalty Sub LLC [Member]                  
Revenue Recognition Royalty and Milestone Revenue Recognized                 $ 30,000