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Note 1 - Significant Accounting Policies - Summary of Revenues (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Royalty revenue $ 489 $ 629 $ 6,810 $ 2,519
Collaborative and other research and development revenues 2,610 4,158 5,726 7,088
Revenues 3,099 4,787 12,536 9,607
US Department of Health and Human Services [Member]        
Collaborative and other research and development revenues 2,161 3,709 2,815 6,033
Shionogi and Co. Ltd [Member]        
Collaborative and other research and development revenues 296 296 592 592
Seqirus UK Limited [Member]        
Collaborative and other research and development revenues $ 153 $ 153 $ 2,319 $ 463