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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Operating activities    
Net loss $ (31,105) $ (39,113)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 344 136
Stock-based compensation expense 4,788 4,491
Amortization of Debt Issuance Costs 439 220
Amortization of premium/discount on investments 86 302
Change in fair value of foreign currency derivative 1,943 6,441
Changes in operating assets and liabilities:    
Receivables 5,443 4,009
Inventory (805) (337)
Prepaid expenses and other assets (87) 1,000
Deferred collaboration expense 35 37
Accounts payable and accrued expenses (975) (8,742)
Interest payable 2,597 2,457
Deferred revenue (897) (927)
Net cash used in operating activities (18,194) (30,026)
Investing activities    
Acquisitions of property and equipment (24) (5,099)
Change in restricted cash (3,811) (2,814)
Purchases of investments (33,070)
Sales and maturities of investments 23,873 19,064
Net cash (used in) provided by investing activities (13,032) 11,151
Financing activities    
Sale of common stock, net 47,750
Net proceeds from common stock issued under stock-based compensation plans 1,068 33
Payment of foreign currency derivative collateral (1,610)
Increase in lease financing obligation 214
Net cash provided by (used in) financing activities 48,818 (1,363)
Increase (decrease) in cash and cash equivalents 17,592 (20,238)
Cash and cash equivalents at beginning of period 22,104 28,899
Cash and cash equivalents at end of period $ 39,696 $ 8,661