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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Operating activities: |  |  |
Net loss | $ (65,782) | $ (55,144) | $ (43,019)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation, amortization, and impairment | 704 | 483 | 180
(Gain) loss on disposal of property and equipment | (12) | 17 |
Stock-based compensation expense | 12,621 | 8,487 | 9,705
Amortization of debt issuance costs | 876 | 558 | 439
Amortization of premium/discount on investments | 157 | 523 | 570
Change in fair value of foreign currency derivative | 966 | (811) | 564
Changes in operating assets and liabilities: |  |  |
Receivables | 2,651 | (2,525) | 3,247
Inventory | 500 | 1,112 | (929)
Prepaid expenses and other assets | 877 | 3,702 | 637
Deferred collaboration expense | 74 | 71 | (102)
Accounts payable and accrued expenses | 3,842 | (10,524) | 13,676
Interest payable | 3,105 | 2,244 | 717
Deferred revenue | (1,722) | (1,631) | 1,199
Net cash used in operating activities: | (41,143) | (53,438) | (13,116)
Investing activities: |  |  |
Acquisition of property and equipment | (328) | (5,277) | (5,122)
Proceeds from sale of property and equipment | 12 | 4 |
Change in restricted cash | (1,740) | 66 | (1,462)
Purchases of investments | (107,787) | (14,106) | (53,830)
Sales and maturities of investments | 43,461 | 42,652 | 42,410
Net cash (used in) provided by investing activities: | (66,382) | 23,339 | (18,004)
Financing activities: |  |  |
Sale of common stock, net | 134,000 |  |
Net proceeds from common stock issued under stock-based compensation plans | 1,581 | 317 | 5,479
Proceeds from senior credit facility |  | 22,658 |
Increase in lease financing obligation | 122 | 329 |
Net cash provided by financing activities: | 135,703 | 23,304 | 5,479
Increase (decrease) in cash and cash equivalents | 28,178 | (6,795) | (25,641)
Cash and cash equivalents at beginning of year | 22,104 | 28,899 | 54,540
Cash and cash equivalents at end of year | $ 50,282 | $ 22,104 | $ 28,899

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