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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenues |  |  |
Product sales, net | $ 1,501 | $ 2,269 | $ 6,291
Royalty revenue | 10,543 | 9,682 | 2,386
Collaborative and other research and development | 13,142 | 14,402 | 39,580
Total revenues | 25,186 | 26,353 | 48,257
Expenses |  |  |
Cost of products sold | 1,142 | 2,297 | 1,368
Research and development | 66,962 | 61,008 | 72,758
Selling, general and administrative | 13,933 | 11,253 | 13,047
Royalty | 560 | 402 | 528
Total operating expenses | 82,597 | 74,960 | 87,701
Loss from operations | (57,411) | (48,607) | (39,444)
Interest and other income | 1,015 | 793 | 535
Interest expense | (8,565) | (6,487) | (5,200)
(Loss) gain on foreign currency derivative | (821) | (843) | 1,090
Net loss | $ (65,782) | $ (55,144) | $ (43,019)
Basic and diluted net loss per common share (in dollars per share) | $ (0.78) | $ (0.75) | $ (0.59)
Weighted average shares outstanding (in shares) | 84,451 | 73,699 | 72,901
Unrealized (loss) gain on available for sale investments | $ (231) | $ 194 | $ (76)
Comprehensive loss | $ (66,013) | $ (54,950) | $ (43,095)

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