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Note 1 - Significant Accounting Policies and Concentrations of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Product sales, net | $ 1,501 | $ 2,269 | $ 6,291
Royalty revenue | 10,543 | 9,682 | 2,386
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | 13,142 | 14,402 | 39,580
Total revenues | 25,186 | 26,353 | 48,257
US Department of Health and Human Services [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | 4,608 | 12,449 | 16,337
Green Cross Corporation [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues |  |  | 132
Shionogi and Co. Ltd [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | 1,184 | 1,184 | 1,184
Seqirus UK Limited [Member] |  |  |
Collaborative and other research and development revenues: |  |  |
Collaborative and other research and development revenues | $ 7,350 | $ 769 | $ 21,927

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