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Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables) | 12 Months Ended
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Dec. 31, 2017
Notes Tables |
Available-for-sale Securities [Table Text Block] |
|  | December 31, 2017
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 60,121 |  |  | $ | 177 |  |  | $ | — |  |  | $ | (122 | ) |  | $ | 60,176 |
Corporate debt securities |  |  | 34,021 |  |  |  | 203 |  |  |  | — |  |  |  | (108 | ) |  |  | 34,116 |
Certificates of deposit |  |  | 11,099 |  |  |  | 32 |  |  |  | 1 |  |  |  | (14 | ) |  |  | 11,118 |
Total investments |  | $ | 105,241 |  |  | $ | 412 |  |  | $ | 1 |  |  | $ | (244 | ) |  | $ | 105,410 |
|  | December 31, 2016
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 20,266 |  |  | $ | 34 |  |  | $ | 2 |  |  | $ | (4 | ) |  | $ | 20,298 |
Corporate debt securities |  |  | 6,179 |  |  |  | 26 |  |  |  | 2 |  |  |  | (8 | ) |  |  | 6,199 |
Certificates of deposit |  |  | 14,962 |  |  |  | 17 |  |  |  | 7 |  |  |  | (11 | ) |  |  | 14,975 |
Total investments |  | $ | 41,407 |  |  | $ | 77 |  |  | $ | 11 |  |  | $ | (23 | ) |  | $ | 41,472 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | 2017 |  | 2016
Maturing in one year or less |  | $ | 64,115 |  |  | $ | 32,546 |
Maturing after one year through two years |  |  | 34,257 |  |  |  | 8,926 |
Maturing after two years |  |  | 7,038 |  |  |  | — |
Total investments |  | $ | 105,410 |  |  | $ | 41,472 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | December 31, 2017
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 42 |  |  | $ | 2,020 |  |  | $ | 2,062 |
Shionogi & Co. Ltd. |  |  | 1,600 |  |  |  | — |  |  |  | 1,600 |
Green Cross Corporation |  |  | 1,388 |  |  |  | 28 |  |  |  | 1,416 |
Mundipharma International Holdings Limited |  |  | 47 |  |  |  | — |  |  |  | 47 |
Seqirus UK Limited |  |  | 825 |  |  |  | 167 |  |  |  | 992 |
Total receivables |  | $ | 3,902 |  |  | $ | 2,215 |  |  | $ | 6,117 |
|  | December 31, 2016
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 3,495 |  |  | $ | 3,495 |
Shionogi & Co. Ltd. |  |  | 3,451 |  |  |  | — |  |  |  | 3,451 |
Green Cross Corporation |  |  | 686 |  |  |  | — |  |  |  | 686 |
Seqirus UK Limited |  |  | 957 |  |  |  | 179 |  |  |  | 1,136 |
Total receivables |  | $ | 5,094 |  |  | $ | 3,674 |  |  | $ | 8,768 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31,
|  | 2017 |  | 2016
Compensation and benefits |  | $ | 2,905 |  |  | $ | 425 |
Development costs |  |  | 6,683 |  |  |  | 7,427 |
Inventory |  |  | — |  |  |  | 705 |
Professional fees |  |  | 729 |  |  |  | 242 |
Duties and taxes |  |  | 148 |  |  |  | 56 |
Other |  |  | 2,234 |  |  |  | 1,981 |
Total accrued expenses |  | $ | 12,699 |  |  | $ | 10,836 |
Schedule of Revenues from Collaborations [Table Text Block] |
|  | 2017 |  | 2016 |  | 2015
Product sales, net |  | $ | 1,501 |  |  | $ | 2,269 |  |  | $ | 6,291 |
Royalty revenue |  |  | 10,543 |  |  |  | 9,682 |  |  |  | 2,386 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 4,608 |  |  |  | 12,449 |  |  |  | 16,337 |
Green Cross Corporation |  |  | — |  |  |  | — |  |  |  | 132 |
Shionogi & Co. Ltd. |  |  | 1,184 |  |  |  | 1,184 |  |  |  | 1,184 |
Seqirus UK Limited |  |  | 7,350 |  |  |  | 769 |  |  |  | 21,927 |
Total collaborative and other research and development revenues |  |  | 13,142 |  |  |  | 14,402 |  |  |  | 39,580 |
Total revenues |  | $ | 25,186 |  |  | $ | 26,353 |  |  | $ | 48,257 |

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