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Note 2 - Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2017
Notes Tables  
Property, Plant and Equipment [Table Text Block]
    2017   2016
Furniture and fixtures   $
566
    $
540
 
Office equipment    
146
     
141
 
Software    
1,125
     
1,117
 
Laboratory equipment    
2,984
     
3,252
 
Leased equipment    
152
     
 
Leasehold improvements    
8,405
     
8,294
 
Building    
1,495
     
1,495
 
     
14,873
     
14,839
 
Less accumulated depreciation and amortization    
(5,327
)    
(4,917
)
Property and equipment, net   $
9,546
    $
9,922