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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) shares in Thousands, $ in Thousands	1 Months Ended	12 Months Ended
	Jun. 30, 2015 USD ($)	Dec. 31, 2017 USD ($) shares	Dec. 31, 2016 USD ($) shares	Dec. 31, 2015 USD ($) shares	Sep. 23, 2016 USD ($)	Mar. 09, 2011 USD ($)
Long-term Line of Credit		$ 16,750	$ 22,777
Restricted Cash and Cash Equivalents, Current		3,286	1,546
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax		(1)	11
Revenues		25,186	26,353	$ 48,257
Advertising Expense		0	0	103
Interest Expense		8,565	6,487	5,200
Amortization of Debt Issuance Costs		876	558	$ 439
Property, Plant and Equipment, Gross		14,873	14,839
Lease Financing Obligation, Net of Current		$ 2,751	$ 2,704
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares		2,067	1,226	3,524
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative		$ 1,787	$ 1,654	$ 564
Derivative, Gain on Derivative		966	811	1,654
Currency Hedge Agreement [Member]
Collateral Already Posted, Aggregate Fair Value		0	0
Birmingham Research Facility [Member]
Interest Expense		299	408
Lease Financing Obligation, Net of Current		2,704	2,704
Capital Leases, Future Minimum Payments Due		4,334
RAPIVAB [Member]
Revenue Recognition, Milestone Method, Revenue Recognized		$ 2,000
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member]
Number of Major Customers		3
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] | Three Customers [Member]
Concentration Risk, Percentage		90.00%
Supplemental NDA for RAPIVAB [Member]
Revenue Recognition, Milestone Method, Revenue Recognized		$ 5,000
Agreement [Member] | CSL [Member] | RAPIVAB [Member]
Proceeds from License Fees Received	$ 33,740
Revenues	21,777
Milestone Payment Maximum	5,000
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Revenue from Sale of Inventory to be Recognized When the Inventory Transfer Is Complete [Member]
Deferred Revenue, Additions	3,740
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Regulatory Support Revenue for Canadian and EU Marketing Approvals, Portion Recognized Ratably Over Expected Period of Involvement [Member]
Deferred Revenue, Additions	1,223
Agreement [Member] | CSL [Member] | RAPIVAB [Member] | Contingent upon EU Marketing Approval [Member]
Proceeds from License Fees Received	$ 7,000
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life		3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life		5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life		7 years
Property, Plant and Equipment, Gross		$ 566	540
Leasehold Improvements [Member]
Property, Plant and Equipment, Gross		$ 8,405	$ 8,294
Leasehold Improvements [Member] | Birmingham Research Facility [Member]
Property, Plant and Equipment, Useful Life		20 years 182 days
Property, Plant and Equipment, Gross				$ 1,589
Maximum [Member]
Maturity Period of High Quality Marketable Securities		3 years
Average Maturity Period of High Quality Marketable Securities		1 year 180 days
Maturity Period of Short Term Investment		1 year
Minimum [Member]
Maturity Period of Short Term Investment		90 days
Long-term Investment Maturity, Minimum		1 year
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current		$ 1,876
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents, Current		1,410
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]
Long-term Line of Credit		$ 23,000			$ 23,000
JPR Royalty Sub LLC [Member]
Revenue Recognition Royalty and Milestone Revenue Recognized						$ 30,000

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