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Note 1 - Significant Accounting Policies and Concentrations of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Product sales, net	$ 1,501	$ 2,269	$ 6,291
Royalty revenue	10,543	9,682	2,386
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	13,142	14,402	39,580
Total revenues	25,186	26,353	48,257
US Department of Health and Human Services [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	4,608	12,449	16,337
Green Cross Corporation [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues			132
Shionogi and Co. Ltd [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	1,184	1,184	1,184
Seqirus UK Limited [Member]
Collaborative and other research and development revenues:
Collaborative and other research and development revenues	$ 7,350	$ 769	$ 21,927

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+ References

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1)
-URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688

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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
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+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.1(a))
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