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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues
Product sales, net	$ 1,501	$ 2,269	$ 6,291
Royalty revenue	10,543	9,682	2,386
Collaborative and other research and development	13,142	14,402	39,580
Total revenues	25,186	26,353	48,257
Expenses
Cost of products sold	1,142	2,297	1,368
Research and development	66,962	61,008	72,758
Selling, general and administrative	13,933	11,253	13,047
Royalty	560	402	528
Total operating expenses	82,597	74,960	87,701
Loss from operations	(57,411)	(48,607)	(39,444)
Interest and other income	1,015	793	535
Interest expense	(8,565)	(6,487)	(5,200)
(Loss) gain on foreign currency derivative	(821)	(843)	1,090
Net loss	$ (65,782)	$ (55,144)	$ (43,019)
Basic and diluted net loss per common share (in dollars per share)	$ (0.78)	$ (0.75)	$ (0.59)
Weighted average shares outstanding (in shares)	84,451	73,699	72,901
Unrealized (loss) gain on available for sale investments	$ (231)	$ 194	$ (76)
Comprehensive loss	$ (66,013)	$ (54,950)	$ (43,095)

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