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Note 8 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent     35.00%    
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability $ 73,474,000        
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount     $ (42,625) $ 19,838 $ 20,339
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued 0   0 $ 0 $ 0
Deferred Tax Assets and Liabilities Revaluated [Member]          
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount (72,000)        
Research Tax Credit Carryforward [Member]          
Tax Credit Carryforward, Amount 59,958   59,958    
Domestic Tax Authority [Member]          
Operating Loss Carryforwards 484,705   484,705    
State and Local Jurisdiction [Member]          
Operating Loss Carryforwards 431,470   431,470    
Accounting Standards Update 2016-09 [Member]          
Deferred Tax Assets, Operating Loss Carryforwards 5,949,000   5,949,000    
Operating Loss Carryforwards, Valuation Allowance $ 3,800   $ 3,800    
Scenario, Forecast [Member]          
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent   21.00%