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Note 8 - Income Taxes - Differences Between the Company's Effective Tax Rate and the Statutory Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income tax benefit at federal statutory rate	$ (23,024)	$ (19,300)	$ (15,057)
State and local income taxes net of federal tax benefit	(1,611)	(1,173)	(819)
Permanent items	910	1,057	560
Rate change	71,155	1,080	1,012
Expiration of attribute carryforwards	918	559	330
Effect of ASU 2016-09	(5,949)
Research and development tax credits	(1,977)	(4,681)	(10,454)
Orphan drug credit	564	1,798	4,307
Other	1,639	822	(218)
Change in valuation allowance	(42,625)	19,838	20,339
Income tax expense	$ 0	$ 0	$ 0

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