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Note 1 - Significant Accounting Policies (Details Textual) shares in Thousands, $ in Thousands |  | 3 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | ---
Jan. 21, 2018 | Mar. 31, 2018 USD ($) shares | Mar. 31, 2017 USD ($) shares | Dec. 31, 2017 USD ($) | Sep. 23, 2016 USD ($) | Dec. 31, 2015 USD ($) | Mar. 09, 2011 USD ($)
Long-term Line of Credit, Total |  | $ 15,114 |  | $ 16,750 |  |  |
Restricted Cash and Cash Equivalents, Current, Total |  | 4,599 |  | 3,286 |  |  |
Loss on Sale of Investments |  | 0 |  |  |  |  |
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax |  | 0 | $ 0 |  |  |  |
Interest Expense, Debt, Total |  | 2,136 | 2,020 |  |  |  |
Amortization of Debt Issuance Costs |  | 232 | 220 |  |  |  |
Interest Expense, Total |  | 2,221 | $ 2,100 |  |  |  |
Lease Financing Obligation, Net of Current |  | $ 2,731 |  | 2,751 |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares |  | 1,775 | 2,762 |  |  |  |
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] |  |  |  |  |  |  |
Number of Major Customers |  | 3 |  |  |  |  |
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] | Three Customers [Member] |  |  |  |  |  |  |
Concentration Risk, Percentage |  | 90.00% |  |  |  |  |
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |  |  |  |
Derivative, Loss on Derivative |  | $ 1,804 | $ 1,543 |  |  |  |
Currency Hedge Agreement [Member] |  |  |  |  |  |  |
Collateral Already Posted, Aggregate Fair Value |  | 0 |  | 0 |  |  |
Birmingham Research Facility [Member] |  |  |  |  |  |  |
Interest Expense, Total |  | 82 | $ 80 |  |  |  |
Lease Financing Obligation, Net of Current |  | 2,703 |  | $ 2,703 |  |  |
Capital Leases, Future Minimum Payments Due, Total |  | $ 4,225 |  |  |  |  |
Computer Equipment [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  | 3 years |  |  |  |  |
Laboratory Equipment, Office Equipment and Software [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  | 5 years |  |  |  |  |
Furniture and Fixtures [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  | 7 years |  |  |  |  |
Leasehold Improvements [Member] | Birmingham Research Facility [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  | 20 years 182 days |  |  |  |  |
Property, Plant and Equipment, Gross, Ending Balance |  |  |  |  |  | $ 1,589 |
Maximum [Member] |  |  |  |  |  |  |
Maturity Period of High Quality Marketable Securities |  | 3 years |  |  |  |  |
Average Maturity Period of High Quality Marketable Securities |  | 1 year 180 days |  |  |  |  |
Maturity Period of Short Term Investment |  | 1 year |  |  |  |  |
Average Maturity for Portfolio Investments |  | 1 year 180 days |  |  |  |  |
Minimum [Member] |  |  |  |  |  |  |
Maturity Period of Short Term Investment |  | 90 days |  |  |  |  |
Long-term Investment Maturity, Minimum |  | 1 year |  |  |  |  |
Royalty Receivable [Member] |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total |  | $ 3,188 |  |  |  |  |
Collateral for Credit [Member] |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total |  | 1,411 |  |  |  |  |
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member] |  |  |  |  |  |  |
Long-term Line of Credit, Total |  | $ 21,275 |  |  | $ 23,000 |  |
JPR Royalty Sub LLC [Member] |  |  |  |  |  |  |
Revenue Recognition Royalty and Milestone Revenue Recognized |  |  |  |  |  |  | $ 30,000
Merger Agreement [Member] |  |  |  |  |  |  |
Idera Exchange Ratio | 0.2 |  |  |  |  |  |
BioCryst Exchange Ratio | 0.5 |  |  |  |  |  |
Merger Agreement [Member] | Baker Brother [Member] | BioCryst [Member] |  |  |  |  |  |  |
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners | 14.00% |  |  |  |  |  |
Merger Agreement [Member] | Baker Brother [Member] | Idera [Member] |  |  |  |  |  |  |
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners | 18.00% |  |  |  |  |  |

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