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Note 1 - Significant Accounting Policies and Concentrations of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2018 | Mar. 31, 2017
Revenues | $ 3,976 | $ 9,437
Royalty [Member] |  |
Revenues | 3,661 | 6,321
Collaborative and Other Research and Development [Member] |  |
Revenues | 315 | 3,116
Collaborative and Other Research and Development [Member] | US Department of Health and Human Services [Member] |  |
Revenues | 315 | 654
Collaborative and Other Research and Development [Member] | Shionogi and Co. Ltd [Member] |  |
Revenues |  | 296
Collaborative and Other Research and Development [Member] | Seqirus UK Limited [Member] |  |
Revenues |  | $ 2,166

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