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Note 1 - Significant Accounting Policies (Tables) | 3 Months Ended
--- | ---
Mar. 31, 2018
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | March 31, 2018
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 44,116 |  |  | $ | 148 |  |  | $ | — |  |  | $ | (205 | ) |  | $ | 44,059 |
Corporate debt securities |  |  | 35,299 |  |  |  | 201 |  |  |  | — |  |  |  | (250 | ) |  |  | 35,250 |
Certificates of deposit |  |  | 9,821 |  |  |  | 30 |  |  |  | — |  |  |  | (21 | ) |  |  | 9,830 |
Total investments |  | $ | 89,236 |  |  | $ | 379 |  |  | $ | — |  |  | $ | (476 | ) |  | $ | 89,139 |
|  | December 31, 2017
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 60,121 |  |  | $ | 177 |  |  | $ | — |  |  | $ | (122 | ) |  | $ | 60,176 |
Corporate debt securities |  |  | 34,021 |  |  |  | 203 |  |  |  | — |  |  |  | (108 | ) |  |  | 34,116 |
Certificates of deposit |  |  | 11,099 |  |  |  | 32 |  |  |  | 1 |  |  |  | (14 | ) |  |  | 11,118 |
Total investments |  | $ | 105,241 |  |  | $ | 412 |  |  | $ | 1 |  |  | $ | (244 | ) |  | $ | 105,410 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | 2018 |  | 2017
Maturing in one year or less |  | $ | 47,540 |  |  | $ | 64,115 |
Maturing after one year through two years |  |  | 38,505 |  |  |  | 34,257 |
Maturing after two years |  |  | 3,094 |  |  |  | 7,038 |
Total investments |  | $ | 89,139 |  |  | $ | 105,410 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | March 31, 2018
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 23 |  |  | $ | 996 |  |  | $ | 1,019 |
Shionogi & Co. Ltd. |  |  | 2,422 |  |  |  | — |  |  |  | 2,422 |
Green Cross Corporation |  |  | 899 |  |  |  | 27 |  |  |  | 926 |
Mundipharma International Holdings Limited |  |  | 22 |  |  |  |  |  |  |  | 22 |
Seqirus UK Limited |  |  | 1,133 |  |  |  | 172 |  |  |  | 1,305 |
Total receivables |  | $ | 4,499 |  |  | $ | 1,195 |  |  | $ | 5,694 |
|  | December 31, 2017
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 42 |  |  | $ | 2,020 |  |  | $ | 2,062 |
Shionogi & Co. Ltd. |  |  | 1,600 |  |  |  | — |  |  |  | 1,600 |
Green Cross Corporation |  |  | 1,388 |  |  |  | 28 |  |  |  | 1,416 |
Mundipharma International Holdings Limited |  |  | 47 |  |  |  | — |  |  |  | 47 |
Seqirus UK Limited |  |  | 825 |  |  |  | 167 |  |  |  | 992 |
Total receivables |  | $ | 3,902 |  |  | $ | 2,215 |  |  | $ | 6,117 |
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block] |
|  | Balance at December 31, 2017 |  | Adjustments due to ASC 606 |  | Balance at January 1, 2018
Assets |  |  |  |  |  |  |  |  |  |  |  |
Deferred collaboration expense |  | $ | 210 |  |  | $ | (58 | ) |  | $ | 152 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  | $ | 8,484 |  |  | $ | (1,184 | ) |  | $ | 7,300 |
Equity |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  | $ | (631,843 | ) |  | $ | 1,126 |  |  | $ | (630,717 | )
|  | March 31, 2018
|  | As Reported |  | Adjustments due to ASC 606 |  | Balances without adoption of ASC 606
Assets |  |  |  |  |  |
Deferred collaboration expense |  | $ | 152 |  |  | $ | 44 |  |  | $ | 196 |
Liabilities |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  | $ | 7,300 |  |  | $ | 888 |  |  | $ | 8,188 |
Equity |  |  |  |  |  |  |  |  |  |  |  |
Accumulated deficit |  | $ | (656,494 | ) |  | $ | 282 |  |  | $ | (656,212 | )
|  | For the Three Months Ended March 31, 2018
|  | As Reported |  | Adjustments due to ASC 606 |  | Balances without adoption of ASC 606
Collaborative and other research and development revenue |  | $ | 315 |  |  | $ | 296 |  |  | $ | 611 |
Research and development expenses |  |  | 18,441 |  |  |  | 14 |  |  |  | 18,455 |
Net loss |  |  | (25,777 | ) |  |  | 282 |  |  |  | (25,495 | )
Basic and diluted net loss per share |  | $ | (0.26 | ) |  | $ | 0.00 |  |  | $ | (0.26 | )
Disaggregation of Revenue [Table Text Block] |
|  | 2018 |  | 2017
Royalty revenues |  | $ | 3,661 |  |  | $ | 6,321 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 315 |  |  |  | 654 |
Shionogi & Co., Ltd. |  |  | — |  |  |  | 296 |
Seqirus UK Limited |  |  | — |  |  |  | 2,166 |
Total collaborative and other research and development revenues |  |  | 315 |  |  |  | 3,116 |
Total revenues |  | $ | 3,976 |  |  | $ | 9,437 |

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