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Note 1 - Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2018

Notes Tables

Debt Securities, Available-for-sale [Table Text Block]

		March 31, 2018
		Amortized Cost				Accrued Interest				Gross Unrealized Gains				Gross Unrealized Losses				Estimated Fair Value
Obligations of the U.S. Government and its agencies		$	44,116			$	148			$	—			$	(205	)		$	44,059
Corporate debt securities			35,299				201				—				(250	)			35,250
Certificates of deposit			9,821				30				—				(21	)			9,830
Total investments		$	89,236			$	379			$	—			$	(476	)		$	89,139

		December 31, 2017
		Amortized Cost				Accrued Interest				Gross Unrealized Gains				Gross Unrealized Losses				Estimated Fair Value
Obligations of the U.S. Government and its agencies		$	60,121			$	177			$	—			$	(122	)		$	60,176
Corporate debt securities			34,021				203				—				(108	)			34,116
Certificates of deposit			11,099				32				1				(14	)			11,118
Total investments		$	105,241			$	412			$	1			$	(244	)		$	105,410

Available For Sale Securities Debt Maturities Fair Value [Table Text Block]

		2018				2017
Maturing in one year or less		$	47,540			$	64,115
Maturing after one year through two years			38,505				34,257
Maturing after two years			3,094				7,038
Total investments		$	89,139			$	105,410

Schedule of Receivables from Collaborations [Table Text Block]

		March 31, 2018
		Billed				Unbilled				Total
U.S. Department of Health and Human Services		$	23			$	996			$	1,019
Shionogi & Co. Ltd.			2,422				—				2,422
Green Cross Corporation			899				27				926
Mundipharma International Holdings Limited			22								22
Seqirus UK Limited			1,133				172				1,305
Total receivables		$	4,499			$	1,195			$	5,694

		December 31, 2017
		Billed				Unbilled				Total
U.S. Department of Health and Human Services		$	42			$	2,020			$	2,062
Shionogi & Co. Ltd.			1,600				—				1,600
Green Cross Corporation			1,388				28				1,416
Mundipharma International Holdings Limited			47				—				47
Seqirus UK Limited			825				167				992
Total receivables		$	3,902			$	2,215			$	6,117

Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]

		Balance at December 31, 2017				Adjustments due to ASC 606				Balance at January 1, 2018
Assets
Deferred collaboration expense		$	210			$	(58	)		$	152
Liabilities
Deferred revenue		$	8,484			$	(1,184	)		$	7,300
Equity
Accumulated deficit		$	(631,843	)		$	1,126			$	(630,717	)

		March 31, 2018
		As Reported				Adjustments due to ASC 606				Balances without adoption of ASC 606
Assets
Deferred collaboration expense		$	152			$	44			$	196
Liabilities
Deferred revenue		$	7,300			$	888			$	8,188
Equity
Accumulated deficit		$	(656,494	)		$	282			$	(656,212	)

		For the Three Months Ended March 31, 2018
		As Reported				Adjustments due to ASC 606				Balances without adoption of ASC 606
Collaborative and other research and development revenue		$	315			$	296			$	611
Research and development expenses			18,441				14				18,455
Net loss			(25,777	)			282				(25,495	)
Basic and diluted net loss per share		$	(0.26	)		$	0.00			$	(0.26	)

Disaggregation of Revenue [Table Text Block]

		2018				2017
Royalty revenues		$	3,661			$	6,321
Collaborative and other research and development revenues:
U.S. Department of Health and Human Services			315				654
Shionogi & Co., Ltd.			—				296
Seqirus UK Limited			—				2,166
Total collaborative and other research and development revenues			315				3,116
Total revenues		$	3,976			$	9,437

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