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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues:
Revenues	$ 3,976	$ 9,437
Expenses
Research and development	18,441	16,770
General and administrative	7,609	3,058
Royalty	140	294
Total operating expenses	26,190	20,122
Loss from operations	(22,214)	(10,685)
Interest and other income	462	109
Interest expense	(2,221)	(2,100)
Loss on foreign currency derivative	(1,804)	(1,543)
Net loss	$ (25,777)	$ (14,219)
Basic and diluted net loss per common share (in dollars per share)	$ (0.26)	$ (0.19)
Weighted average shares outstanding (in shares)	98,592	75,167
Unrealized (loss) gain on available for sale investments	$ (233)	$ 9
Comprehensive loss	(26,010)	(14,210)
Royalty [Member]
Revenues:
Revenues	3,661	6,321
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 315	$ 3,116

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