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Note 2 - Stock-based Compensation (Details Textual) $ / shares in Units, shares in Thousands, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Aug. 31, 2013 shares | Mar. 31, 2018 shares | Jun. 30, 2018 USD ($) $ / shares shares | Jun. 30, 2017 USD ($) $ / shares | Dec. 31, 2014 shares | Dec. 31, 2017 shares
Number of Stock-based Compensation Plans |  |  | 2 |  |  |
Allocated Share-based Compensation Expense, Total |  |  | $ 4,987 | $ 4,788 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Total |  |  | 14,509 |  |  |
Employee Service Share-based Compensation Nonvested Awards Compensation Cost Expected to be Recognized For Remainder of Fiscal Year |  |  | 3,927 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Two |  |  | 5,845 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Three |  |  | 3,363 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Four |  |  | 1,372 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Five |  |  | 2 |  |  |
Incentive Plan [Member] |  |  |  |  |  |
Allocated Share-based Compensation Expense, Total |  |  | $ 4,904 | $ 4,652 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ / shares |  |  | $ 4.13 | $ 3.74 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  |  | 0.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | shares |  |  | 329 |  |  | 468
Incentive Plan [Member] | Employee Stock Option [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  |  | 0.00% |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Minimum [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  |  | 5 years |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Maximum [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  |  | 10 years |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Non-employee Directors [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, First Vesting Period After Grant Date |  |  | 1 year |  |  |
Incentive Plan [Member] | Employee Stock Option [Member] | Vest 25% Each Year Until Fully Vested [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 25.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  | 4 years |  |  |
Incentive Plan [Member] | Performance Shares [Member] |  |  |  |  |  |
Allocated Share-based Compensation Expense, Total |  |  | $ 0 |  |  |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | shares | 1,032 |  |  |  | 1,250 |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | August 2013 [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 75.00% |  |  |
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage |  |  | 25.00% |  |  |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | December 2014 [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 30.00% |  |  |
Share-based Compensation Arrangement by Shar-based Payment Award, Awards Unvested, Percentage |  |  | 70.00% |  |  |
Incentive Plan [Member] | Restricted Stock Units (RSUs) [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Ending Balance | shares |  |  | 27 |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |
Allocated Share-based Compensation Expense, Total |  |  | $ 83 | $ 136 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized | shares |  |  | 1,475 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | shares |  |  | 277 |  |  |
Percentage of Salary to Purchase Common Stock, Maximum |  |  | 15.00% |  |  |
Percentage of Common Stock Shares, Beginning |  |  | 85.00% |  |  |
Percentage of Common Stock Shares, Ending |  |  | 85.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee | shares |  |  | 3 |  |  |
Shar-based Compensation Arrangement by Shar-based Payment Award, Maximum Number of Shares Per Employee, Amount |  |  | $ 25 |  |  |
Stock Issued During Period, Shares, Employee Stock Purchase Plans | shares |  | 49 |  |  |  |

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- Definition The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901 + Details
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