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Note 1 - Significant Accounting Policies (Tables)
6 Months Ended
Jun. 30, 2018
Notes Tables  
Debt Securities, Available-for-sale [Table Text Block]
    June 30, 2018
   
Amortized
Cost
 
Accrued
Interest
 
Gross
Unrealized
Gains
 
Gross
Unrealized
Losses
 
Estimated
Fair Value
Obligations of the U.S. Government and its agencies   $
47,023
    $
136
    $
    $
(204
)   $
46,955
 
Corporate debt securities    
33,465
     
199
     
     
(226
)    
33,438
 
Certificates of deposit    
6,985
     
24
     
     
(22
)    
6,987
 
                                         
Total investments   $
87,473
    $
359
    $
    $
(452
)   $
87,380
 
    December 31, 2017
   
Amortized
Cost
 
Accrued
Interest
 
Gross
Unrealized
Gains
 
Gross
Unrealized
Losses
 
Estimated
Fair Value
Obligations of the U.S. Government and its agencies   $
60,121
    $
177
    $
    $
(122
)   $
60,176
 
Corporate debt securities    
34,021
     
203
     
     
(108
)    
34,116
 
Certificates of deposit    
11,099
     
32
     
1
     
(14
)    
11,118
 
                                         
Total investments   $
105,241
    $
412
    $
1
    $
(244
)   $
105,410
 
Available For Sale Securities Debt Maturities Fair Value [Table Text Block]
    2018   2017
Maturing in one year or less   $
53,636
    $
64,115
 
Maturing after one year through two years    
33,744
     
34,257
 
Maturing after two years    
     
7,038
 
                 
Total investments   $
87,380
    $
105,410
 
Schedule of Receivables from Collaborations [Table Text Block]
    June 30, 2018
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $
87
    $
1,090
    $
1,177
 
Shionogi & Co. Ltd.    
27
     
     
27
 
Green Cross Corporation    
51
     
27
     
78
 
Mundipharma International Holdings Limited    
43
     
     
43
 
Seqirus UK Limited    
1,017
     
     
1,017
 
                         
Total receivables   $
1,225
    $
1,117
    $
2,342
 
    December 31, 2017
    Billed   Unbilled   Total
U.S. Department of Health and Human Services   $
42
    $
2,020
    $
2,062
 
Shionogi & Co. Ltd.    
1,600
     
     
1,600
 
Green Cross Corporation    
1,388
     
28
     
1,416
 
Mundipharma International Holdings Limited    
47
     
     
47
 
Seqirus UK Limited    
825
     
167
     
992
 
                         
Total receivables   $
3,902
    $
2,215
    $
6,117
 
Schedule of New Accounting Pronouncements and Changes in Accounting Principles [Table Text Block]
   
Balance at
December 31, 2017
 
Adjustments due to
ASC 606
 
Balance at
January 1, 2018
Assets                        
Deferred collaboration expense   $
210
    $
(58
)   $
152
 
Liabilities                        
Deferred revenue   $
8,484
    $
(1,184
)   $
7,300
 
Equity                        
Accumulated deficit   $
(631,843
)   $
1,126
    $
(630,717
)
    June 30, 2018
    As Reported   Adjustments due to
ASC 606
  Balances without
adoption of ASC 606
Assets            
Deferred collaboration expense   $
12
    $
29
    $
41
 
Liabilities                        
Deferred revenue   $
300
    $
592
    $
892
 
Equity                        
Accumulated deficit   $
(674,940
)   $
563
    $
(674,377
)
    For the Three Months Ended June 30, 2018
    As Reported  
Adjustments due to
ASC 606
 
Balances without
adoption of ASC 606
Collaborative and other research and development revenue   $
12,352
    $
296
    $
12,648
 
Research and development expenses    
21,010
     
14
     
21,024
 
Net loss    
(18,446
)    
282
     
(18,164
)
Basic and diluted net loss per share   $
(0.19
)   $
0.01
    $
(0.18
)
    For the Six Months Ended June 30, 2018
    As Reported  
Adjustments due to
ASC 606
 
Balances without
adoption of ASC 606
Collaborative and other research and development revenue   $
12,667
    $
592
    $
13,259
 
Research and development expenses    
39,451
     
29
     
39,480
 
Net loss    
(44,223
)    
563
     
(43,660
)
Basic and diluted net loss per share   $
(0.45
)   $
0.01
    $
(0.44
)
Disaggregation of Revenue [Table Text Block]
    Three Months   Six Months
    2018   2017   2018   2017
Royalty revenue   $
142
    $
489
    $
3,803
    $
6,810
 
Collaborative and other research and development revenues:                                
U.S. Department of Health and Human Services    
352
     
2,161
     
667
     
2,815
 
Shionogi & Co. Ltd.    
     
296
     
     
592
 
Seqirus UK Limited    
12,000
     
153
     
12,000
     
2,319
 
Total collaborative and other research and development revenues    
12,352
     
2,610
     
12,667
     
5,726
 
                                 
Total revenues   $
12,494
    $
3,099
    $
16,470
    $
12,536