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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues:
Revenues	$ 12,494	$ 3,099	$ 16,470	$ 12,536
Expenses
Research and development	21,010	15,759	39,451	32,529
General and administrative	9,492	2,834	17,101	5,892
Royalty	243	22	383	316
Total operating expenses	30,745	18,615	56,935	38,737
Loss from operations	(18,251)	(15,516)	(40,465)	(26,201)
Interest and other income	493	203	955	312
Interest expense	(2,195)	(2,094)	(4,416)	(4,194)
Gain (loss) on foreign currency derivative	1,507	521	(297)	(1,022)
Net loss	$ (18,446)	$ (16,886)	$ (44,223)	$ (31,105)
Basic and diluted net loss per common share (in dollars per share)	$ (0.19)	$ (0.21)	$ (0.45)	$ (0.40)
Weighted average shares outstanding (in shares)	98,787	80,418	98,690	77,807
Unrealized gain (loss) on available for sale investments	$ 24	$ (12)	$ (209)	$ (3)
Comprehensive loss	(18,422)	(16,898)	(44,432)	(31,108)
Royalty [Member]
Revenues:
Revenues	142	489	3,803	6,810
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 12,352	$ 2,610	$ 12,667	$ 5,726

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