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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Operating activities    
Net loss $ (44,223) $ (31,105)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 377 344
Stock-based compensation expense 4,987 4,788
Amortization of debt issuance costs 455 439
Amortization of premium/discount on investments 140 86
Change in fair value of foreign currency derivative 1,185 1,943
Changes in operating assets and liabilities:    
Receivables 3,775 5,443
Inventory (221) (805)
Prepaid expenses and other assets (347) (87)
Deferred collaboration expense 140 35
Accounts payable and accrued expenses 4,447 (975)
Interest payable 2,737 2,597
Deferred revenue (7,000) (897)
Net cash used in operating activities (33,548) (18,194)
Investing activities    
Acquisitions of property and equipment (221) (24)
Purchases of investments (16,754) (33,070)
Sales and maturities of investments 34,435 23,873
Net cash provided by (used in) investing activities 17,460 (9,221)
Financing activities    
Sale of common stock, net 47,750
Payment of senior credit facility (3,450)
Net proceeds from common stock issued under stock-based compensation plans 736 1,068
Increase in lease financing obligation (37)
Net cash (used in) provided by financing activities (2,751) 48,818
(Decrease) increase in cash, cash equivalents and restricted cash (18,839) 21,403
Cash, cash equivalents and restricted cash at beginning of period 53,568 23,650
Cash, cash equivalents and restricted cash at end of period $ 34,729 $ 45,053