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Note 1 - Significant Accounting Policies - Summary of Revenues (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017
Revenues | $ 1,454 | $ 8,760 | $ 17,924 | $ 21,296
Product [Member] |  |  |  |
Revenues |  | 1,501 |  | 1,501
Royalty [Member] |  |  |  |
Revenues | 523 | 442 | 4,326 | 7,252
Collaborative and Other Research and Development [Member] |  |  |  |
Revenues | 931 | 6,817 | 13,598 | 12,543
Collaborative and Other Research and Development [Member] | US Department of Health and Human Services [Member] |  |  |  |
Revenues | 931 | 1,490 | 1,598 | 4,305
Collaborative and Other Research and Development [Member] | Shionogi and Co. Ltd [Member] |  |  |  |
Revenues |  | 296 |  | 888
Collaborative and Other Research and Development [Member] | Seqirus UK Limited [Member] |  |  |  |
Revenues |  | $ 5,031 | $ 12,000 | $ 7,350

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