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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Operating activities    
Net loss $ (73,820) $ (46,239)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 572 522
Stock-based compensation expense 7,072 10,307
Amortization of debt issuance costs 676 658
Amortization of premium/discount on investments 152 125
Change in fair value of foreign currency derivative 606 1,858
Changes in operating assets and liabilities:    
Receivables 2,723 (217)
Inventory (821) 500
Prepaid expenses and other assets (1,063) 17
Deferred collaboration expense 144 51
Accounts payable and accrued expenses 3,947 1,303
Interest payable (1,668) 1,715
Deferred revenue (7,100) (1,224)
Net cash used in operating activities (68,580) (30,624)
Investing activities    
Acquisitions of property and equipment (262) (213)
Purchases of investments (43,158) (39,572)
Sales and maturities of investments 51,355 32,527
Net cash provided by (used in) investing activities 7,935 (7,258)
Financing activities    
Sale of common stock, net 53,400 133,500
Proceeds from senior credit facility 10,353
Payment of senior credit facility (4,025)
Net proceeds from common stock issued under stock-based compensation plans 1,495 1,491
(Decrease) increase in lease financing obligation (56) 139
Net cash provided by financing activities 61,167 135,130
Increase in cash, cash equivalents and restricted cash 522 97,248
Cash, cash equivalents and restricted cash at beginning of period 53,568 23,650
Cash, cash equivalents and restricted cash at end of period $ 54,090 $ 120,898