<SEC-DOCUMENT>0000930413-18-002429.txt : 20180731
<SEC-HEADER>0000930413-18-002429.hdr.sgml : 20180731
<ACCEPTANCE-DATETIME>20180731160028
ACCESSION NUMBER:		0000930413-18-002429
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20180731
DATE AS OF CHANGE:		20180731

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		18981084

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>c91744_sc13da.htm
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549<BR>
<BR>
Schedule 13D/A</B></P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Under the Securities Exchange Act of
1934<BR>
(Amendment No. 2)*</B></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>



<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">BioCryst Pharmaceuticals Inc.</P>



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<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Common Stock</P>



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<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">09058V103</P>



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<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ron Panzier</B></P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Great Point Partners, LLC</B></P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>165 Mason Street, 3<SUP>rd</SUP> Floor</B></P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Greenwich, CT 06830</B></P>



<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(203) 971-3300</P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, Address and Telephone Number of Person
Authorized to</P>



<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Receive Notices and Communications)</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">July 31, 2018</P>



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<P STYLE="font: bold 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event which Requires Filing of
this Statement)</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><FONT STYLE="font-size: 11pt">If the
filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule
13D, and is filing this schedule because of &sect;&sect;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note</B>: Schedule filed in paper format
shall include a signed original and five copies of the schedule, including all exhibits. See &sect;240.13d-7 for other parties
to whom copies are to be sent.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">*The remainder of this
cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover
page.</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 11pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">The information required
in the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities
Exchange Act of 1934 (&ldquo;<U>Act</U>&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be
subject to all other provisions of the Act (however, see the Notes).</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="border: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; vertical-align: top; width: 5%"><FONT STYLE="font-size: 10pt">1</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; width: 95%; padding-top: 6pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><BR></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Great Point Partners, LLC&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="border-bottom: Black 1px solid; border-left: Black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; border-right: Black 1px solid; vertical-align: top"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt; text-align: left; padding-left: 6pt; border-right: Black 1px solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT>&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-right: Black 1px solid; border-bottom: Black 1px solid; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT>&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC
    Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source
    of Funds (See Instructions) AF</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship
    or Place of Organization Delaware</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 25%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number
    of Shares</FONT><BR>
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><BR>
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 70%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole
    Voting Power 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared
    Voting Power 7,478,275</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom"><FONT STYLE="font-size: 10pt">Sole
    Dispositive Power 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared
    Dispositive Power 7,478,275</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt; line-height: 92%">11</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 95%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person 7,478,275</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">12</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">13</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent
    of Class Represented by Amount in Row (11) 7.57%<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">14</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding: 6pt 6pt 1pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid; padding-left: 36pt">IA</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid">&nbsp;</P>

</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><SUP>1</SUP> Based on a total of 98,821,091 shares outstanding,
as reported by the Issuer on a Schedule 14A  filed with the Securities and Exchange Commission on May 30, 2018.</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt">1</FONT></TD>
    <TD STYLE="border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; padding-right: 6pt; padding-left: 6pt; width: 95%; padding-top: 6pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons.<BR>
        <BR></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Dr. Jeffrey R. Jay, M.D.</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; vertical-align: top"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD STYLE="border-right: black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt; text-align: left; padding-left: 6pt; border-right: Black 1px solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT>&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-right: Black 1px solid; border-bottom: Black 1px solid; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT>&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC
    Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source
    of Funds (See Instructions) AF</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship
    or Place of Organization United States</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 25%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number
    of Shares</FONT><BR>
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><BR>
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 70%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole
    Voting Power 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared
    Voting Power 7,478,275</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom"><FONT STYLE="font-size: 10pt">Sole
    Dispositive Power 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared
    Dispositive Power 7,478,275</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt; line-height: 92%">11</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 95%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person 7,478,275</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">12</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">13</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent
    of Class Represented by Amount in Row (11) 7.57%<SUP>2</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">14</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding: 6pt 6pt 1pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; padding-left: 36pt; border-bottom: Black 1px solid">IN</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid">&nbsp;</P>

</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><SUP>2</SUP> Based on a total of 98,821,091 shares outstanding, as reported by the Issuer on a Schedule 14A filed with the
Securities and Exchange Commission on May 30, 2018.</P>

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    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt">1</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; width: 95%; padding-top: 6pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons<BR>
        <BR></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Mr. David Kroin</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-right: Black 1px solid; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT>&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR>
    <TD STYLE="vertical-align: top; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt; text-align: left; border-bottom: Black 1px solid; border-right: Black 1px solid; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT>&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    </TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC
    Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source
    of Funds (See Instructions) AF</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship
    or Place of Organization United States</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 25%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number
    of Shares</FONT><BR>
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><BR>
    <FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 70%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole
    Voting Power 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared
    Voting Power 7,478,275</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom"><FONT STYLE="font-size: 10pt">Sole
    Dispositive Power 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared
    Dispositive Power 7,478,275</FONT></TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt; line-height: 92%">11</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 95%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person 7,478,275</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">12</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">13</FONT></TD>
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; font: 10pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent
    of Class Represented by Amount in Row (11) 7.57%<SUP>3</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; font: 10pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%">14</FONT></TD>
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding: 6pt 6pt 1pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; padding-left: 36pt; border-bottom: Black 1px solid">IN</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 25pt 0 0; border-bottom: Black 1px solid">&nbsp;</P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><SUP>3</SUP> Based on a total of 98,821,091 shares outstanding, as reported by the Issuer on a Schedule 14A filed with the
Securities and Exchange Commission on May 30, 2018.</P>
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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt"><FONT STYLE="font-weight: normal">This
Amendment No. 2 to Schedule 13D (this &ldquo;<U>Amendment</U>&rdquo;) is being filed by the undersigned to amend and supplement
the Schedule 13D originally filed on February 16, 2018, as amended by that certain Amendment No. 1 to Schedule 13D filed on June
20, 2018 (as amended, the &ldquo;<U>Original Filing</U>&rdquo;). Unless otherwise indicated, all capitalized terms shall have the
same meaning as provided in the Original Filing. Any reference to &ldquo;this Schedule 13D&rdquo; in the Original Filing or in
this Amendment shall refer to the Original Filing as amended by this Amendment.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 76.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">Item&nbsp;4.</TD>
    <TD>Purpose of Transaction</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">Item 4 is hereby
amended and restated as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">As recommended by
the Reporting Persons, at the meeting of shareholders, the proposed merger of the Issuer with IDRA was rejected. The Reporting
Persons intend to continue to review the operations of the Issuer including, without limitation, the Issuer&rsquo;s financial position
and strategic direction and actions taken or not taken by the board of directors of the Issuer, and may as a result thereof choose
to offer guidance or advice to the board of directors or management, or recommend other actions that the Reporting Persons believe
at the time would enhance shareholder value. No such guidance, advice or recommended actions have been formulated to date by the
Reporting Persons. The Reporting Persons may also from time to time choose to adjust their ownership of the Issuer&rsquo;s securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>


<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">Item&nbsp;5.</TD>
    <TD>Interest in Securities of the Issuer</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">Item
5 is hereby amended and restated as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BVF
is the record holder of 2,222,425 shares of Common Stock (the &ldquo;BVF Shares&rdquo;). Such shares constitute 2.25% of the shares
of Common Stock outstanding, computed in accordance with Rule 13d-3. BVF shares voting and dispositive power over the BVF Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">BOVF
is the record holder of 2,873,069 shares of Common Stock (the &ldquo;BOVF Shares&rdquo;). Such shares constitute 2.91% of the shares
of Common Stock outstanding, computed in accordance with Rule 13d-3. BOVF shares voting and dispositive power over the BOVF Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">GEF-SMA
is the record holder of 2,215,114 shares of Common Stock (the &ldquo;GEF-SMA Shares&rdquo;). Such shares constitute 2.24% of the
shares of Common Stock outstanding, computed in accordance with Rule 13d-3. GEF-SMA shares voting and dispositive power over the
GEF-SMA Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">GEF-PS
is the record holder of 167,667 shares of Common Stock (the &ldquo;GEF-PS Shares&rdquo;). Such shares constitute 0.17% of the shares
of Common Stock outstanding, computed in accordance with Rule 13d-3. GEF-PS shares voting and dispositive power over the GEF-PS
Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">Great
Point is the investment manager of each of BVF, BOVF, GEF-SMA and GEF-PS and by virtue of such status may be deemed to be the beneficial
owner of the BVF Shares, the BOVF Shares, the GEF-SMA Shares and the GEF-PS Shares. Each of Dr. Jay, as senior managing member
of Great Point, and Mr. Kroin, and special managing member of Great Point, has shared voting and investment power with respect
to the BVF Shares, the BOVF Shares, the GEF-SMA Shares and the GEF-PS Shares and may be deemed to be the beneficial owner of such
shares. Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BOVF Shares, the GEF-SMA Shares
and the GEF-PS Shares except to the extent of any pecuniary interest, and this statement shall not be deemed to be an admission
that they are the beneficial owners of such securities.</P>


<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt; text-indent: -72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; font: bold 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 72pt">Item&nbsp;7.</TD>
    <TD>Material to be Filed as Exhibits</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 72pt">The following documents
are filed as exhibits and are incorporated herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 72pt">EXHIBIT A: Joint Filing Agreement, dated as of July 31,
2018.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><FONT STYLE="font-weight: normal"><I>Signature</I></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt"></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">Date: &nbsp;July 31, 2018</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left"><FONT STYLE="font-size: 10pt"><B>Great Point Partners, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 70%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 1%"><FONT STYLE="font-size: 10pt">By: </FONT></TD>
    <TD STYLE="text-align: left; width: 3%; border-bottom: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 22%; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left; width: 4%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Name: Dr. Jeffrey R. Jay</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Title: Senior Managing Member</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, individually</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Mr. David Kroin, individually</FONT></TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13D/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36pt; text-align: left">&nbsp;</TD>
    <TD STYLE="width: 36pt; text-align: left">(i)</TD>
    <TD STYLE="text-align: justify">Each of them is individually eligible to use the Schedule 13D/A to which this Exhibit
    is attached, and such Schedule 13D/A is filed on behalf of each of them; and</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">(ii)</TD>
    <TD STYLE="text-align: justify">Each of them is responsible for the timely filing of such Schedule 13D/A and any amendments thereto,
    and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible
    for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows
    or has reason to believe that such information is inaccurate.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36pt; text-align: left"><FONT STYLE="font-size: 10pt">Date:</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">July 31, 2018</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 252pt; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left"><B>Great Point Partners, LLC</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 70%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 1%"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="text-align: left; width: 3%; border-bottom: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 22%; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt"> /s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left; width: 4%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Name: Dr. Jeffrey R. Jay</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Title: Senior Managing Member</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, individually</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid">&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Mr. David Kroin, individually</FONT></TD></TR>
</TABLE>



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