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Note 8 - Income Taxes (Details Textual) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent |  | 21.00% | 35.00% | 35.00%
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability | $ 73,474 |  |  |
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount |  | $ 26,040 | $ (42,625) | $ 19,838
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total | 0 | 0 | 0 | $ 0
Research Tax Credit Carryforward [Member] |  |  |  |
Tax Credit Carryforward, Amount |  | 65,485 |  |
Domestic Tax Authority [Member] |  |  |  |
Operating Loss Carryforwards, Total |  | 569,314 |  |
State and Local Jurisdiction [Member] |  |  |  |
Operating Loss Carryforwards, Total |  | $ 496,816 |  |
Accounting Standards Update 2016-09 [Member] |  |  |  |
Deferred Tax Assets, Operating Loss Carryforwards, Total | $ 5,949,000 |  | $ 5,949,000 |

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