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Note 8 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Net federal and state operating losses | $ 137,234 | $ 117,787
Research and development credits | 59,509 | 55,208
Deferred revenue |  | 1,854
Stock-based compensation | 7,108 | 6,424
Other | 5,258 | 2,046
Total deferred tax assets | 209,109 | 183,319
Fixed assets | (418) | (421)
Foreign currency derivative | (231) | (478)
Total deferred tax liabilities | (649) | (899)
Valuation allowance | (208,460) | (182,420)
Net deferred tax assets |  |

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