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Note 7 - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2018
Notes Tables |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | Year Ended December 31,
|  | 2018 |  | 2017 |  | 2016
Research and development |  | $ | 6,867 |  |  | $ | 9,602 |  |  | $ | 6,088 |
General and administrative |  |  | 2,529 |  |  |  | 3,019 |  |  |  | 2,399 |
Total stock-based compensation expense |  | $ | 9,396 |  |  | $ | 12,621 |  |  | $ | 8,487 |
Share-based Compensation, Activity [Table Text Block] |
|  | Awards Available |  | Options Outstanding |  | Weighted Average Exercise Price
Balance at December 31, 2015 |  |  | 16 |  |  |  | 10,671 |  |  | $ | 7.50 |
Plan amendment |  |  | 3,800 |  |  |  | - |  |  |  | - |
Restricted stock awards granted |  |  | (34 | ) |  |  | - |  |  |  | - |
Restricted stock awards cancelled |  |  | 22 |  |  |  | - |  |  |  | - |
Stock option awards granted |  |  | (2,248 | ) |  |  | 2,248 |  |  |  | 3.20 |
Stock option awards exercised |  |  | - |  |  |  | (107 | ) |  |  | 2.63 |
Stock option awards cancelled |  |  | 717 |  |  |  | (717 | ) |  |  | 10.78 |
Balance at December 31, 2016 |  |  | 2,273 |  |  |  | 12,095 |  |  |  | 6.55 |
Plan amendment |  |  | 1,000 |  |  |  | - |  |  |  | - |
Restricted stock awards granted |  |  | (22 | ) |  |  | - |  |  |  | - |
Restricted stock awards cancelled |  |  | 12 |  |  |  | - |  |  |  | - |
Stock option awards granted |  |  | (3,915 | ) |  |  | 3,915 |  |  |  | 5.33 |
Stock option awards exercised |  |  | - |  |  |  | (438 | ) |  |  | 3.50 |
Stock option awards cancelled |  |  | 1,120 |  |  |  | (1,120 | ) |  |  | 9.72 |
Balance at December 31, 2017 |  |  | 468 |  |  |  | 14,452 |  |  |  | 6.06 |
Plan amendment |  |  | 4,400 |  |  |  | - |  |  |  | - |
Restricted stock awards granted |  |  | (13 | ) |  |  | - |  |  |  | - |
Restricted stock awards cancelled |  |  | - |  |  |  | - |  |  |  | - |
Stock option awards granted |  |  | (4,272 | ) |  |  | 4,272 |  |  |  | 7.15 |
Stock option awards exercised |  |  | - |  |  |  | (1,011 | ) |  |  | 2.92 |
Stock option awards cancelled |  |  | 222 |  |  |  | (222 | ) |  |  | 7.44 |
Balance at December 31, 2018 |  |  | 805 |  |  |  | 17,491 |  |  | $ | 6.49 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2018 |  | 2017 |  | 2016
Expected Life |  |  | 5.5 |  |  |  | 5.5 |  |  |  | 5.5 |
Expected Volatility |  |  | 82 | % |  |  | 82 | % |  |  | 82 | %
Expected Dividend Yield |  |  | 0.0 | % |  |  | 0.0 | % |  |  | 0.0 | %
Risk-Free Interest Rate |  |  | 2.7 | % |  |  | 2.0 | % |  |  | 1.4 | %
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block] |
|  |  |  |  | Outstanding |  | Exercisable
Range |  |  |  | Number |  | Weighted Average Remaining Life |  | Weighted Average Exercise Price |  | Number |  | Weighted Average Exercise Price
$ | 0 | to | 3 |  | 1,266 |  |  | 4.1 |  |  | $ | 1.66 |  |  |  | 1,191 |  |  | $ | 1.58 |
| 3 | to | 6 |  | 7,778 |  |  | 6.8 |  |  |  | 4.69 |  |  |  | 3,937 |  |  |  | 4.50 |
| 6 | to | 9 |  | 4,768 |  |  | 8.7 |  |  |  | 7.06 |  |  |  | 883 |  |  |  | 6.85 |
| 9 | to | 12 |  | 2,980 |  |  | 6.5 |  |  |  | 10.90 |  |  |  | 1,711 |  |  |  | 10.96 |
| 12 | to | 15 |  | 604 |  |  | 6.0 |  |  |  | 12.29 |  |  |  | 403 |  |  |  | 12.35 |
| 15 | to | 18 |  | 95 |  |  | 6.5 |  |  |  | 15.39 |  |  |  | 71 |  |  |  | 15.39 |
$ | 0 | to | 18 |  | 17,491 |  |  | 7.0 |  |  | $ | 6.49 |  |  |  | 8,196 |  |  | $ | 6.16 |
Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Non-Vested Stock Option Awards |  | Weighted Average Grant-Date Fair Value
Balance December 31, 2017 |  |  | 7,202 |  |  | $ | 4.56 |
Stock option awards granted |  |  | 4,272 |  |  |  | 4.92 |
Stock option awards vested |  |  | (2,065 | ) |  |  | 4.33 |
Stock option awards forfeited |  |  | (114 | ) |  |  | 4.12 |
Balance December 31, 2018 |  |  | 9,295 |  |  | $ | 4.78 |

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