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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Operating activities: |  |  |
Net loss | $ (101,252) | $ (65,782) | $ (55,144)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 770 | 704 | 483
Loss (gain) on disposal of property and equipment | 7 | (12) | 17
Stock-based compensation expense | 9,396 | 12,621 | 8,487
Amortization of debt issuance costs | 885 | 876 | 558
Amortization of premium/discount on investments | 110 | 157 | 523
Change in fair value of foreign currency derivative | 1,049 | 966 | (811)
Changes in operating assets and liabilities: |  |  |
Receivables | 1,824 | 2,651 | (2,525)
Inventory | (1,649) | 500 | 1,112
Prepaid expenses and other assets | (1,009) | 877 | 3,702
Deferred collaboration expense | 143 | 74 | 71
Accounts payable and accrued expenses | 4,487 | 3,842 | (10,524)
Interest payable | (247) | 3,105 | 2,244
Deferred revenue | (7,079) | (1,722) | (1,631)
Net cash used in operating activities: | (92,565) | (41,143) | (53,438)
Investing activities: |  |  |
Acquisition of property and equipment | (366) | (328) | (5,277)
Proceeds from sale of property and equipment |  | 12 | 4
Purchases of investments | (62,614) | (107,787) | (14,106)
Sales and maturities of investments | 67,748 | 43,461 | 42,652
Net cash provided by (used in) investing activities: | 4,768 | (64,642) | 23,273
Financing activities: |  |  |
Sale of common stock, net | 53,400 | 134,000 |
Net proceeds from common stock issued under stock-based compensation plans | 2,852 | 1,581 | 317
Proceeds from senior credit facility | 10,353 |  | 22,658
Payment of senior credit facility | (4,025) |  |
(Decrease) increase in lease financing obligation | (76) | 122 | 329
Net cash provided by financing activities: | 62,504 | 135,703 | 23,304
(Decrease) increase in cash, cash equivalents and restricted cash | (25,293) | 29,918 | (6,861)
Cash, cash equivalents and restricted cash at beginning of year | 53,568 | 23,650 | 30,511
Cash, cash equivalents and restricted cash at end of year | $ 28,275 | $ 53,568 | $ 23,650

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
Name: | us-gaap_ShareBasedCompensation
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | duration