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v3.19.1

Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Revenues: |  |  |
Revenues | $ 20,653 | $ 25,186 | $ 26,353
Expenses |  |  |
Cost of products sold |  | 1,142 | 2,297
Research and development | 84,888 | 66,962 | 61,008
Selling, general and administrative | 29,514 | 13,933 | 11,253
Royalty | 471 | 560 | 402
Total operating expenses | 114,873 | 82,597 | 74,960
Loss from operations | (94,220) | (57,411) | (48,607)
Interest and other income | 2,252 | 1,015 | 793
Interest expense | (9,176) | (8,565) | (6,487)
Loss on foreign currency derivative | (108) | (821) | (843)
Net loss | (101,252) | (65,782) | (55,144)
Unrealized (loss) gain on available for sale investments | (54) | (231) | 194
Net comprehensive loss | $ (101,306) | $ (66,013) | $ (54,950)
Basic and diluted net loss per common share (in dollars per share) | $ (0.98) | $ (0.78) | $ (0.75)
Weighted average shares outstanding (in shares) | 103,185 | 84,451 | 73,699
Product [Member] |  |  |
Revenues: |  |  |
Revenues |  | $ 1,501 | $ 2,269
Royalty [Member] |  |  |
Revenues: |  |  |
Revenues | 6,101 | 10,543 | 9,682
Collaborative and Other Research and Development [Member] |  |  |
Revenues: |  |  |
Revenues | $ 14,552 | $ 13,142 | $ 14,402

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