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Note 2 - Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2018
Notes Tables  
Property, Plant and Equipment [Table Text Block]
    2018   2017
Furniture and fixtures   $
573
    $
566
 
Office equipment    
152
     
146
 
Software    
1,125
     
1,125
 
Laboratory equipment    
3,329
     
2,984
 
Leased equipment    
143
     
152
 
Leasehold improvements    
8,413
     
8,405
 
Building    
1,495
     
1,495
 
     
15,230
     
14,873
 
Less accumulated depreciation and amortization    
(6,095
)    
(5,327
)
Property and equipment, net   $
9,135
    $
9,546