XML 41 R27.htm IDEA: XBRL DOCUMENT v3.19.1

Note 8 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		2018				2017				2016
Income tax benefit at federal statutory rate (21% for 2018 and 2017 and 35 % for 2016)		$	(21,263	)		$	(23,024	)		$	(19,300	)
State and local income taxes net of federal tax benefit			(2,547	)			(1,611	)			(1,173	)
Permanent items			503				910				1,057
Rate change			(29	)			71,155				1,080
Expiration of attribute carryforwards			2,183				918				559
Effect of ASU 2016-09			-				(5,949	)			-
Research and development tax credits			(4,905	)			(1,977	)			(4,681	)
Orphan drug credit			-				564				1,798
Other			18				1,639				822
Change in valuation allowance			26,040				(42,625	)			19,838
Income tax expense		$	-			$	-			$	-

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

		2018				2017
Balance at January 1,		$	4,750			$	4,255
Additions to current period tax positions			1,226				495
Additions to prior period tax positions			-				-
Reductions to prior period tax provisions			-				-
Balance at December 31,		$	5,976			$	4,750

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		2018				2017
Deferred tax assets:
Net federal and state operating losses		$	137,234			$	117,787
Research and development credits			59,509				55,208
Deferred revenue			-				1,854
Stock-based compensation			7,108				6,424
Other			5,258				2,046
Total deferred tax assets			209,109				183,319
Deferred tax liabilities:
Fixed assets			(418	)			(421	)
Foreign currency derivative			(231	)			(478	)
Total deferred tax liabilities			(649	)			(899	)
Valuation allowance			(208,460	)			(182,420	)
Net deferred tax assets		$	-			$	-

X

- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

+ Details

Name:	us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

+ Details

Name:	us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Tabular disclosure of the change in unrecognized tax benefits.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 55
-Paragraph 217
-URI http://asc.fasb.org/extlink&oid=109238393&loc=d3e36027-109320

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 15A
-URI http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319

+ Details

Name:	us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	nonnum:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- References

No definition available.

+ Details

Name:	us-gaap_TableTextBlock
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration