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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2018
USD ($)
shares
Dec. 31, 2017
USD ($)
shares
Dec. 31, 2016
USD ($)
shares
Jul. 20, 2018
USD ($)
Sep. 23, 2016
USD ($)
Dec. 31, 2015
USD ($)
Mar. 09, 2011
USD ($)
Long-term Line of Credit, Total $ 25,372 $ 16,750          
Restricted Cash and Cash Equivalents, Current, Total 1,544 3,286          
Loss on Sale of Investments 0            
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax 2 1          
Interest Expense, Debt, Total 9,176 8,565 $ 6,487        
Amortization of Debt Issuance Costs 885 876 558        
Property, Plant and Equipment, Gross, Ending Balance 15,230 14,873          
Interest Expense, Total 9,176 8,565 $ 6,487        
Lease Financing Obligation, Net of Current $ 2,703 $ 2,751          
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares 2,274 2,067 1,226        
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member]              
Number of Major Customers 3            
RAPIVAB [Member] | Customer Concentration Risk [Member] | Sales Revenue, Product Line [Member] | Three Customers [Member]              
Concentration Risk, Percentage 90.00%            
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]              
Derivative, Loss on Derivative $ 1,049 $ 1,787 $ 1,654        
Derivative, Gain on Derivative 941 966 811        
Currency Hedge Agreement [Member]              
Collateral Already Posted, Aggregate Fair Value 0 0          
Birmingham Research Facility [Member]              
Interest Expense, Total 337 299 $ 408        
Lease Financing Obligation, Net of Current 2,703 2,704          
Capital Leases, Future Minimum Payments Due, Total $ 3,890            
Computer Equipment [Member]              
Property, Plant and Equipment, Useful Life 3 years            
Laboratory Equipment, Office Equipment and Software [Member]              
Property, Plant and Equipment, Useful Life 5 years            
Furniture and Fixtures [Member]              
Property, Plant and Equipment, Useful Life 7 years            
Property, Plant and Equipment, Gross, Ending Balance $ 573 566          
Leasehold Improvements [Member]              
Property, Plant and Equipment, Gross, Ending Balance $ 8,413 $ 8,405          
Leasehold Improvements [Member] | Birmingham Research Facility [Member]              
Property, Plant and Equipment, Useful Life 20 years 182 days            
Property, Plant and Equipment, Gross, Ending Balance           $ 1,589  
Maximum [Member]              
Maturity Period of High Quality Marketable Securities 3 years            
Average Maturity Period of High Quality Marketable Securities 1 year 180 days            
Maturity Period of Short Term Investment 1 year            
Average Maturity for Portfolio Investments 1 year 180 days            
Minimum [Member]              
Maturity Period of Short Term Investment 90 days            
Long-term Investment Maturity, Minimum 1 year            
Designated for Interest on Notes [Member]              
Restricted Cash and Cash Equivalents, Current, Total $ 131            
Collateral for Credit [Member]              
Restricted Cash and Cash Equivalents, Current, Total 1,413            
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]              
Long-term Line of Credit, Total $ 30,000     $ 30,000 $ 23,000    
JPR Royalty Sub LLC [Member]              
Revenue Recognition Royalty and Milestone Revenue Recognized             $ 30,000