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Note 1 - Significant Accounting Policies and Concentrations of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues	$ 2,729	$ 1,454	$ 12,494	$ 3,976	$ 3,890	$ 8,760	$ 3,099	$ 9,437	$ 20,653	$ 25,186	$ 26,353
Product [Member]
Revenues										1,501	2,269
Royalty [Member]
Revenues									6,101	10,543	9,682
Collaborative and Other Research and Development [Member]
Revenues									14,552	13,142	14,402
Collaborative and Other Research and Development [Member] | US Department of Health and Human Services [Member]
Revenues									2,552	4,608	12,449
Collaborative and Other Research and Development [Member] | Shionogi and Co. Ltd [Member]
Revenues										1,184	1,184
Collaborative and Other Research and Development [Member] | Seqirus UK Limited [Member]
Revenues									$ 12,000	$ 7,350	$ 769

X

- Definition

Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130539-203045

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130543-203045

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