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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Revenues:
Revenues	$ 20,653	$ 25,186	$ 26,353
Expenses
Cost of products sold		1,142	2,297
Research and development	84,888	66,962	61,008
Selling, general and administrative	29,514	13,933	11,253
Royalty	471	560	402
Total operating expenses	114,873	82,597	74,960
Loss from operations	(94,220)	(57,411)	(48,607)
Interest and other income	2,252	1,015	793
Interest expense	(9,176)	(8,565)	(6,487)
Loss on foreign currency derivative	(108)	(821)	(843)
Net loss	(101,252)	(65,782)	(55,144)
Unrealized (loss) gain on available for sale investments	(54)	(231)	194
Net comprehensive loss	$ (101,306)	$ (66,013)	$ (54,950)
Basic and diluted net loss per common share (in dollars per share)	$ (0.98)	$ (0.78)	$ (0.75)
Weighted average shares outstanding (in shares)	103,185	84,451	73,699
Product [Member]
Revenues:
Revenues		$ 1,501	$ 2,269
Royalty [Member]
Revenues:
Revenues	6,101	10,543	9,682
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 14,552	$ 13,142	$ 14,402

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Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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