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Note 8 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
 1 Months Ended 12 Months Ended
Dec. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent   21.00% 35.00% 35.00%
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability $ 73,474      
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount   $ 26,040 $ (42,625) $ 19,838
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total 0 0 0 $ 0
Research Tax Credit Carryforward [Member]        
Tax Credit Carryforward, Amount   65,485    
Domestic Tax Authority [Member]        
Operating Loss Carryforwards, Total   569,314    
State and Local Jurisdiction [Member]        
Operating Loss Carryforwards, Total   $ 496,816    
Accounting Standards Update 2016-09 [Member]        
Deferred Tax Assets, Operating Loss Carryforwards, Total $ 5,949,000   $ 5,949,000