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Note 8 - Income Taxes - Differences Between the Company's Effective Tax Rate and the Statutory Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income tax benefit at federal statutory rate (21% for 2018 and 2017 and 35 % for 2016)	$ (21,263)	$ (23,024)	$ (19,300)
State and local income taxes net of federal tax benefit	(2,547)	(1,611)	(1,173)
Permanent items	503	910	1,057
Rate change	(29)	71,155	1,080
Expiration of attribute carryforwards	2,183	918	559
Effect of ASU 2016-09		(5,949)
Research and development tax credits	(4,905)	(1,977)	(4,681)
Orphan drug credit		564	1,798
Other	18	1,639	822
Change in valuation allowance	26,040	(42,625)	19,838
Income tax expense	$ 0	$ 0	$ 0

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