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Note 8 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Net federal and state operating losses	$ 137,234	$ 117,787
Research and development credits	59,509	55,208
Deferred revenue		1,854
Stock-based compensation	7,108	6,424
Other	5,258	2,046
Total deferred tax assets	209,109	183,319
Fixed assets	(418)	(421)
Foreign currency derivative	(231)	(478)
Total deferred tax liabilities	(649)	(899)
Valuation allowance	(208,460)	(182,420)
Net deferred tax assets

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