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v3.19.1

Note 1 - Significant Accounting Policies (Tables) | 3 Months Ended
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Mar. 31, 2019
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | March 31, 2019
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 46,201 |  |  | $ | 183 |  |  | $ | 31 |  |  | $ | (55 | ) |  | $ | 46,360 |
Corporate debt securities |  |  | 34,316 |  |  |  | 226 |  |  |  | 15 |  |  |  | (81 | ) |  |  | 34,476 |
Certificates of deposit |  |  | 3,559 |  |  |  | 12 |  |  |  | 6 |  |  |  | (5 | ) |  |  | 3,572 |
Total investments |  | $ | 84,076 |  |  | $ | 421 |  |  | $ | 52 |  |  | $ | (141 | ) |  | $ | 84,408 |
|  | December 31, 2018
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 50,613 |  |  | $ | 176 |  |  | $ | 15 |  |  | $ | (131 | ) |  | $ | 50,673 |
Corporate debt securities |  |  | 45,793 |  |  |  | 254 |  |  |  | 4 |  |  |  | (171 | ) |  |  | 45,880 |
Certificates of deposit |  |  | 3,559 |  |  |  | 14 |  |  |  | — |  |  |  | (14 | ) |  |  | 3,559 |
Total investments |  | $ | 99,965 |  |  | $ | 444 |  |  | $ | 19 |  |  | $ | (316 | ) |  | $ | 100,112 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | March 31, 2019 |  | December 31, 2018
Maturing in one year or less |  | $ | 72,753 |  |  | $ | 77,736 |
Maturing after one year through two years |  |  | 11,655 |  |  |  | 22,376 |
Total investments |  | $ | 84,408 |  |  | $ | 100,112 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | March 31, 2019
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 673 |  |  |  | 1,014 |  |  |  | 1,687 |
Shionogi & Co. Ltd. |  |  | 1,451 |  |  |  | — |  |  |  | 1,451 |
Green Cross Corporation |  |  | 642 |  |  |  | — |  |  |  | 642 |
Mundipharma International Holdings Limited |  |  | 21 |  |  |  | — |  |  |  | 21 |
Seqirus UK Limited |  |  | 1,175 |  |  |  | 26 |  |  |  | 1,201 |
Total receivables |  | $ | 3,962 |  |  | $ | 1,040 |  |  | $ | 5,002 |
|  | December 31, 2018
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 1,525 |  |  | $ | 1,525 |
Shionogi & Co. Ltd. |  |  | 854 |  |  |  | — |  |  |  | 854 |
Green Cross Corporation |  |  | 876 |  |  |  | 28 |  |  |  | 904 |
Mundipharma International Holdings Limited |  |  | 44 |  |  |  | — |  |  |  | 44 |
Seqirus UK Limited |  |  | 940 |  |  |  | 26 |  |  |  | 966 |
Total receivables |  | $ | 2,714 |  |  | $ | 1,579 |  |  | $ | 4,293 |
Disaggregation of Revenue [Table Text Block] |
|  | 2019 |  | 2018
Product sales |  | $ | 1,679 |  |  | $ | — |
Royalty revenues |  |  | 2,322 |  |  |  | 3,661 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 1,886 |  |  |  | 315 |
Total collaborative and other research and development revenues |  |  | 1,886 |  |  |  | 315 |
Total revenues |  | $ | 5,887 |  |  | $ | 3,976 |

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