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Note 2 - Stock-based Compensation (Details Textual) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Aug. 31, 2013 | Jun. 30, 2019 | Jun. 30, 2019 | Jun. 30, 2018 | Dec. 31, 2014 | Dec. 31, 2018
Share-based Payment Arrangement, Expense |  |  | $ 8,702 | $ 4,987 |  |
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total |  | $ 29,218 | 29,218 |  |  |
Employee Service Share-based Compensation Nonvested Awards Compensation Cost Expected to be Recognized For Remainder of Fiscal Year |  | 8,827 | 8,827 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Two |  | 8,574 | 8,574 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Three |  | 6,529 | 6,529 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Four |  | 5,103 | 5,103 |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Five |  | $ 185 | 185 |  |  |
Incentive Plan [Member] |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  | $ 8,535 | $ 4,904 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value |  |  | $ 4.69 | $ 4.13 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  |  | 0.00% | 0.00% |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price |  |  | $ 6.90 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  | 4,102 | 4,102 |  |  | 805
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  |  | 0.00% |  |  |
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] | Minimum [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  |  | 5 years |  |  |
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] | Maximum [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term |  |  | 10 years |  |  |
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] | Non-employee Directors [Member] |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  | $ 2,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, First Vesting Period After Grant Date |  |  | 1 year |  |  |
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] | Vest 25% Each Year Until Fully Vested [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 25.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  | 4 years |  |  |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | 1,032 |  |  |  | 1,250 |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | August 2013 [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 75.00% |  |  |
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] | December 2014 [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 30.00% |  |  |
Inducement Plan [Member] |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  | $ 16 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  | 4 years |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  | 242 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value |  |  | $ 3.94 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  | 10 years |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price |  |  | $ 5.81 |  |  |
Inducement Plan [Member] | Vest 25% Each Year Until Fully Vested [Member] |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  | 25.00% |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  | $ 151 | $ 83 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized |  | 1,475 | 1,475 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  | 187 | 187 |  |  |
Percentage of Salary to Purchase Common Stock, Maximum |  |  | 15.00% |  |  |
Percentage of Common Stock Shares, Beginning |  |  | 85.00% |  |  |
Percentage of Common Stock Shares, Ending |  |  | 85.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee |  |  | 3 |  |  |
Shar-based Compensation Arrangement by Shar-based Payment Award, Maximum Number of Shares Per Employee, Amount |  | $ 25 | $ 25 |  |  |
Stock Issued During Period, Shares, Employee Stock Purchase Plans |  |  | 47 |  |  |

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