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v3.19.2

Note 1 - Significant Accounting Policies (Details Textual) $ in Thousands | 3 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Jun. 30, 2019 USD ($) shares | Jun. 30, 2018 USD ($) shares | Jun. 30, 2019 USD ($) shares | Jun. 30, 2018 USD ($) shares | Dec. 31, 2018 USD ($) | Sep. 23, 2016 USD ($) | Mar. 09, 2011 USD ($)
Long-term Line of Credit, Total | $ 49,847 |  | $ 49,847 |  | $ 25,372 |  |
Restricted Cash and Cash Equivalents, Current, Total | 4,629 |  | 4,629 |  | 1,544 |  |
Interest Expense, Debt, Total | 3,035 | $ 2,195 | 5,761 | $ 4,416 |  |  |
Amortization of Debt Issuance Costs | $ 341 | $ 223 | $ 596 | $ 455 |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | shares | 1,927 | 1,939 | 2,528 | 1,854 |  |  |
RAPIVAB [Member] | Customer Concentration Risk [Member] | Revenue, Product and Service Benchmark [Member] |  |  |  |  |  |  |
Number of Major Customers |  |  | 3 |  |  |  |
RAPIVAB [Member] | Customer Concentration Risk [Member] | Revenue, Product and Service Benchmark [Member] | Three Customers [Member] |  |  |  |  |  |  |
Concentration Risk, Percentage |  |  | 90.00% |  |  |  |
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |  |  |  |
Derivative, Loss on Derivative |  |  | $ 646 | $ 1,186 |  |  |
Derivative, Gain on Derivative |  |  | 830 | $ 889 |  |  |
Currency Hedge Agreement [Member] |  |  |  |  |  |  |
Collateral Already Posted, Aggregate Fair Value | $ 0 |  | $ 0 |  | $ 0 |  |
Computer Equipment [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  | 3 years |  |  |  |
Laboratory Equipment, Office Equipment and Software [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  | 5 years |  |  |  |
Furniture and Fixtures [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life |  |  | 7 years |  |  |  |
Maximum [Member] |  |  |  |  |  |  |
Maturity Period of High Quality Marketable Securities |  |  | 3 years |  |  |  |
Average Maturity Period of High Quality Marketable Securities |  |  | 1 year 180 days |  |  |  |
Maturity Period of Short Term Investment |  |  | 1 year |  |  |  |
Average Maturity for Portfolio Investments |  |  | 1 year 180 days |  |  |  |
Minimum [Member] |  |  |  |  |  |  |
Long-term Investment Maturity, Minimum |  |  | 1 year |  |  |  |
Royalty Receivable [Member] |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 3,210 |  | $ 3,210 |  |  |  |
Collateral for Credit [Member] |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 1,419 |  | 1,419 |  |  |  |
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member] |  |  |  |  |  |  |
Long-term Line of Credit, Total | $ 50,000 |  | $ 50,000 |  |  | $ 23,000 |
JPR Royalty Sub LLC [Member] |  |  |  |  |  |  |
Revenue Recognition Royalty and Milestone Revenue Recognized |  |  |  |  |  |  | $ 30,000

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