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Note 1 - Significant Accounting Policies (Tables) | 6 Months Ended
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Jun. 30, 2019
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | June 30, 2019
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of the U.S. Government and its agencies |  | $ | 32,488 |  |  | $ | 144 |  |  | $ | 50 |  |  | $ | (13 | ) |  | $ | 32,669 |
Corporate debt securities |  |  | 25,731 |  |  |  | 147 |  |  |  | 24 |  |  |  | (27 | ) |  |  | 25,875 |
Certificates of deposit |  |  | 3,559 |  |  |  | 18 |  |  |  | 8 |  |  |  | (1 | ) |  |  | 3,584 |
Total investments |  | $ | 61,778 |  |  | $ | 309 |  |  | $ | 82 |  |  | $ | (41 | ) |  | $ | 62,128 |
|  | December 31, 2018
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 50,613 |  |  | $ | 176 |  |  | $ | 15 |  |  | $ | (131 | ) |  | $ | 50,673 |
Corporate debt securities |  |  | 45,793 |  |  |  | 254 |  |  |  | 4 |  |  |  | (171 | ) |  |  | 45,880 |
Certificates of deposit |  |  | 3,559 |  |  |  | 14 |  |  |  | — |  |  |  | (14 | ) |  |  | 3,559 |
Total investments |  | $ | 99,965 |  |  | $ | 444 |  |  | $ | 19 |  |  | $ | (316 | ) |  | $ | 100,112 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | June 30, 2019 |  | December 31, 2018
Maturing in one year or less |  | $ | 61,387 |  |  | $ | 77,736 |
Maturing after one year through two years |  |  | 741 |  |  |  | 22,376 |
Total investments |  | $ | 62,128 |  |  | $ | 100,112 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | June 30, 2019
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 998 |  |  | $ | 989 |  |  | $ | 1,987 |
Shionogi & Co. Ltd. |  |  | 96 |  |  |  | — |  |  |  | 96 |
Green Cross Corporation |  |  | 542 |  |  |  | — |  |  |  | 542 |
Mundipharma International Holdings Limited |  |  | 49 |  |  |  | — |  |  |  | 49 |
Seqirus UK Limited |  |  | 902 |  |  |  | 26 |  |  |  | 928 |
Total receivables |  | $ | 2,587 |  |  | $ | 1,015 |  |  | $ | 3,602 |
|  | December 31, 2018
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | — |  |  | $ | 1,525 |  |  | $ | 1,525 |
Shionogi & Co. Ltd. |  |  | 854 |  |  |  | — |  |  |  | 854 |
Green Cross Corporation |  |  | 876 |  |  |  | 28 |  |  |  | 904 |
Mundipharma International Holdings Limited |  |  | 44 |  |  |  | — |  |  |  | 44 |
Seqirus UK Limited |  |  | 940 |  |  |  | 26 |  |  |  | 966 |
Total receivables |  | $ | 2,714 |  |  | $ | 1,579 |  |  | $ | 4,293 |
Disaggregation of Revenue [Table Text Block] |
|  | Three Months |  | Six Months
|  | 2019 |  | 2018 |  | 2019 |  | 2018
Product sales |  | $ | — |  |  | $ | — |  |  | $ | 1,679 |  |  | $ | — |
Royalty revenue |  |  | 696 |  |  |  | 142 |  |  |  | 3,018 |  |  |  | 3,803 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 752 |  |  |  | 352 |  |  |  | 2,638 |  |  |  | 667 |
Seqirus UK Limited |  |  | — |  |  |  | 12,000 |  |  |  | — |  |  |  | 12,000 |
Total collaborative and other research and development revenues |  |  | 752 |  |  |  | 12,352 |  |  |  | 2,638 |  |  |  | 12,667 |
Total revenues |  | $ | 1,448 |  |  | $ | 12,494 |  |  | $ | 7,335 |  |  | $ | 16,470 |

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