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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenues:
Revenues	$ 1,448	$ 12,494	$ 7,335	$ 16,470
Expenses
Cost of product sales			1,399
Research and development	27,681	21,010	55,174	39,451
General and administrative	8,659	9,492	14,897	17,101
Royalty	26	243	113	383
Total operating expenses	36,366	30,745	71,583	56,935
Loss from operations	(34,918)	(18,251)	(64,248)	(40,465)
Interest and other income	547	493	1,143	955
Interest expense	(3,035)	(2,195)	(5,761)	(4,416)
(Loss) gain on foreign currency derivative	(223)	1,507	183	(297)
Net loss	(37,629)	(18,446)	(68,683)	(44,223)
Unrealized gain (loss) on available for sale investments	130	24	338	(209)
Comprehensive loss	$ (37,499)	$ (18,422)	$ (68,345)	$ (44,432)
Basic and diluted net loss per common share (in dollars per share)	$ (0.34)	$ (0.19)	$ (0.62)	$ (0.45)
Weighted average shares outstanding (in shares)	110,338	98,787	110,253	98,690
Product [Member]
Revenues:
Revenues			$ 1,679
Royalty [Member]
Revenues:
Revenues	696	142	3,018	3,803
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 752	$ 12,352	$ 2,638	$ 12,667

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Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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