<SEC-DOCUMENT>0000930413-19-000073.txt : 20190111
<SEC-HEADER>0000930413-19-000073.hdr.sgml : 20190111
<ACCEPTANCE-DATETIME>20190111172357
ACCESSION NUMBER:		0000930413-19-000073
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20190111
DATE AS OF CHANGE:		20190111

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		19523038

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>c92673_sc13g.htm
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        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 3pt 0 0; text-align: center"><B><A NAME="bmkPageNumber"></A>UNITED
        STATES<BR>
        SECURITIES AND EXCHANGE COMMISSION<BR>
        Washington, D.C. 20549<BR>
        <BR>
        Schedule 13G</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 3pt 0 0; text-align: center"><B><BR>
        Under the Securities Exchange Act of 1934<BR>
        <BR>
        (Amendment No. )*</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 3pt 0 0; text-align: center"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 3pt 0 0"><B>&nbsp;</B></P></TD></TR>
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    <TD STYLE="border-bottom: Black 1pt solid; font: bold 12pt Times New Roman, Times, Serif; padding-top: 12pt; text-align: center"><FONT STYLE="font-size: 10pt">BioCryst Pharmaceuticals Inc.</FONT></TD></TR>
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Name of Issuer)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 12pt Times New Roman, Times, Serif; padding-top: 24pt; text-align: center"><FONT STYLE="font-size: 10pt">Common Stock</FONT></TD></TR>
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Title of Class of Securities)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 12pt Times New Roman, Times, Serif; padding-top: 24pt; text-align: center"><FONT STYLE="font-size: 10pt">09058V103</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(CUSIP Number)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; font: bold 12pt Times New Roman, Times, Serif; padding-top: 24pt; text-align: center"><FONT STYLE="font-size: 10pt">December 31, 2018</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 10pt">(Date of Event which Requires Filing of this Statement)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 10pt">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">[X]<FONT STYLE="font-size: 10pt">&#9;Rule 13d-1(b)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">[_]<FONT STYLE="font-size: 10pt">&#9;Rule 13d-1(c)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">[_]<FONT STYLE="font-size: 10pt">&#9;Rule 13d-1(d)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 6pt; text-align: justify; text-indent: 0in">*The remainder of this
cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover
page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">The information required in the remainder
of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of
1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify"><B>Persons who respond to the collection
of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.</B></P>







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    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 2 of 9 Pages</TD></TR>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>1.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">Great Point Partners, LLC</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">37-1475292</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>2.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>3.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SEC USE ONLY</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>4.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.25in">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" ROWSPAN="4" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 12pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH</B></FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>5.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SOLE VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>6.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">7,622,256</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>7.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>8.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">7,622,256</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>9.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">7,622,256</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>10.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES</B> (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>11.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; margin: 6pt 0 0; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">6.95%</FONT><A HREF="#note_ftn1" NAME="note_ftnref1" STYLE="font-size: 65%; vertical-align: 35%">1</A></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>12.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">IA</P></TD></TR>

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<TD STYLE="width: 0"></TD><TD STYLE="width: 0.25in"><A HREF="#note_ftnref1" NAME="note_ftn1" STYLE="font-size: 65%; vertical-align: 35%">1</A></TD><TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal">Based on a total
of 109,641,044 shares outstanding, as reported in the Issuer&rsquo;s Form 10-Q filed with the SEC on November 8, 2018</FONT></TD></TR></TABLE>


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    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 3  of 9 Pages</TD></TR>
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>1.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">Dr. Jeffrey R. Jay, M.D.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>2.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>3.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SEC USE ONLY</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>4.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" ROWSPAN="4" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH</B></FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>5.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SOLE VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>6.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">7,622,256</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>7.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>8.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">7,622,256</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>9.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">7,622,256</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>10.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES</B> (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>11.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">6.95%<SUP>1</SUP></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>12.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">IN</P></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 4  of 9 Pages</TD></TR>
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>1.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">Mr. David Kroin</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>2.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 3pt; padding-bottom: 3pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>3.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>SEC USE ONLY</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>4.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">USA</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3" ROWSPAN="4" STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH</B></FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>5.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SOLE VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>6.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SHARED VOTING POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">7,622,256</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>7.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0; text-align: center">0</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>8.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-align: center">7,622,256</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>9.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">7,622,256</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>10.</B></FONT></TD>
    <TD COLSPAN="4" STYLE="vertical-align: top; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
        SHARES</B> (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0">&nbsp;</P></TD>
    <TD STYLE="vertical-align: bottom; padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0">[_]</P>
        <P STYLE="font: 10pt/92% Times New Roman, Times, Serif; margin: 3pt 0 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>11.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">6.95%<SUP>1</SUP></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>12.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 6pt 0 0; text-indent: 0.5in">IN</P></TD></TR>
</TABLE>
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    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 5  of 9 Pages</TD></TR>
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    <TD ROWSPAN="3" STYLE="width: 15%; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font: 12pt Times New Roman, Times, Serif; text-align: center"><BR STYLE="clear: both">
<BR STYLE="clear: both">
<FONT STYLE="font-size: 10pt; line-height: 92%"><B>Item 1.</B></FONT></TD>
    <TD STYLE="width: 85%; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font: 12pt Tahoma, Helvetica, Sans-Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0 39pt; text-indent: -39pt">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Name
        of Issuer</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0 0.25in; text-indent: 21pt">BioCryst Pharmaceuticals Inc.</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0 39pt; text-indent: -39pt">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Address
        of Issuer&rsquo;s Principal Executive Offices</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0 39pt; text-indent: 0pt">4505 Emperor Blvd., Suite 200, Durham
        NC 27703</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>Item 2.</B></FONT></TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD></TR>
<TR>
    <TD ROWSPAN="5" STYLE="vertical-align: top; font: 12pt Times New Roman, Times, Serif; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0">(a)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Name of Person
        Filing</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0 66pt">Great Point Partners, LLC<BR>
        Dr. Jeffrey R. Jay, M.D.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 66pt">Mr. David Kroin</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-align: justify">The Reporting Persons have entered into
        a Joint Filing Agreement, dated January 11, 2019, a copy of which is filed with this Schedule 13G as <U>Exhibit A</U>, pursuant
        to which the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1)
        under the Act.</P></TD></TR>
<TR>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0">(b)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Address of Principal
        Business Office, or if none, Residence</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-indent: 39pt">The address of the principal business office
        of each of the Reporting Persons is</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 56.9pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 56.9pt">165 Mason Street, 3rd Floor</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 56.9pt">Greenwich, CT 06830</P></TD></TR>
<TR>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0">(c)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Citizenship</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-align: justify">Great Point Partners, LLC is a limited
        liability company organized under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen of the United States.
        Mr. David Kroin is a citizen of the United States.</P></TD></TR>
<TR>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0">(d)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Title of Class
        of Securities</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-indent: 0.5in">Common Stock</P></TD></TR>
<TR>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0">(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CUSIP Number</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-indent: 0.5in">09058V103</P></TD></TR>
</TABLE>

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    <TD ROWSPAN="11" STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 15%"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>Item 3.</B></FONT></TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 85%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>If this statement is filed pursuant to &sect;240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o) </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(d)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(e)&#9;</FONT>[X]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; margin: 8pt 0 0 48pt; text-indent: -55pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(f)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;An
        employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F).&nbsp;</FONT></P></TD></TR>
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<P STYLE="margin: 0">&nbsp;</P>
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<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 6  of 9 Pages</TD></TR>
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    <TD ROWSPAN="11" STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 15%"><FONT STYLE="font-size: 10pt; line-height: 92%"></FONT></TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 85%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">
    </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"></FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(g)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;A parent holding company or control person in accordance with &sect;240.13d-1(b)(1)(ii)(G).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(h)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(i)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 48pt; text-indent: -48pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(j)&#9;</FONT>[_]<FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&#9;Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).</FONT><BR>
<BR>
</TD></TR>
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    <TD ROWSPAN="11" STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 15%"><FONT STYLE="font-size: 10pt; line-height: 92%"><B>Item 4.</B></FONT></TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 85%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>Ownership</B></FONT></TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Biomedical Value Fund, L.P. (&ldquo;<U>BVF</U>&rdquo;) is the record owner of 2,268,470 shares of Common Stock (the &ldquo;<U>BVF Shares</U>&rdquo;). Great Point Partners, LLC (&ldquo;<U>Great Point</U>&rdquo;) is the investment manager of BVF, and by virtue of such status may be deemed to be the beneficial owner of the BVF Shares. Each of Dr. Jeffrey R. Jay, M.D. (&ldquo;<U>Dr. Jay</U>&rdquo;), as senior managing member of Great Point, and Mr. David Kroin (&ldquo;<U>Mr. Kroin</U>&rdquo;), as special managing member of Great Point, has voting and investment power with respect to the BVF Shares, and therefore may be deemed to be the beneficial owner of the BVF Shares. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Biomedical Offshore Value Fund, Ltd. (&ldquo;<U>BOVF</U>&rdquo;) is the record owner of 2,932,592 shares of Common Stock (the &ldquo;<U>BOVF Shares</U>&rdquo;). Great Point is the investment manager of BOVF, and by virtue of such status may be deemed to be the beneficial owner of the BOVF Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BOVF Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">GEF-SMA, LP (&ldquo;<U>GEF-SMA</U>&rdquo;) is the record owner of 2,261,008 shares of Common Stock (the &ldquo;<U>GEF-SMA Shares</U>&rdquo;). Great Point is the investment manager of GEF-SMA, and by virtue of such status may be deemed to be the beneficial owner of the GEF-SMA Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the GEF-SMA Shares, and therefore may be deemed to be the beneficial owner of the GEF-SMA Shares. </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-align: justify">Class D Series of GEF-PS, L.P. (&ldquo;<U>GEF-PS</U>&rdquo;)
        is the record owner of 160,186 shares of Common Stock (the &ldquo;<U>GEF-PS Shares</U>&rdquo;). Great Point is the investment manager
        of GEF-PS, and by virtue of such status may be deemed to be the beneficial owner of the GEF-PS Shares. Each of Dr. Jay, as senior
        managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with
        respect to the GEF-PS Shares, and therefore may be deemed to be the beneficial owner of the GEF-PS Shares.</P></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-align: justify">Notwithstanding the above, Great Point,
        Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BOVF Shares, the GEF-SMA Shares and the GEF-PS Shares
        described above, except to the extent of their respective pecuniary interests.</p></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 6pt; padding-left: 6pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 8pt 0 0; text-align: justify">Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.</p></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.&#9;<B>Great Point Partners, LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)&#9;Amount beneficially owned: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)&#9;Percent of class: 6.95%</FONT><SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)&#9;Number of shares as to which the person has:</FONT></TD></TR>
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&#9;Sole power to vote or to direct the vote: &nbsp;0 </FONT></TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>
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    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 7 of 9 Pages</TD></TR>
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 15%">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt; width: 85%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&#9;Shared power to vote or to direct the vote: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&#9;Sole power to dispose or to direct the disposition of: &nbsp;0 </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&#9;Shared power to dispose or to direct the disposition of: 7,622,256</FONT></TD></TR>
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<P STYLE="margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 15%">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt; width: 85%"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">2.&#9;<B>Dr. Jeffrey R. Jay, M.D.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)&#9;Amount beneficially owned: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)&#9;Percent of class: 6.95%<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)&#9;Number of shares as to which the person has:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&#9;Sole power to vote or to direct the vote: 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&#9;Shared power to vote or to direct the vote: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&#9;Sole power to dispose or to direct the disposition of: 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&#9;Shared power to dispose or to direct the disposition of: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">3.&#9;<B>Mr. David Kroin</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(a)&#9;Amount beneficially owned: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(b)&#9;Percent of class: 6.95%<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">(c)&#9;Number of shares as to which the person has:</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(i)&#9;Sole power to vote or to direct the vote: 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(ii)&#9;Shared power to vote or to direct the vote: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iii)&#9;Sole power to dispose or to direct the disposition of: 0</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(iv)&#9;Shared power to dispose or to direct the disposition of: 7,622,256</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 8pt; padding-right: 6pt; padding-left: 6pt">&nbsp;</TD></TR>
</TABLE>
<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 11pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 5.</TD><TD>Ownership of Five Percent or Less of a Class</TD></TR>                                                                                                                       <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">If
this statement is being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be the
beneficial owner of more than five percent of the class of securities, check the following [ ].</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 11pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 6.</TD><TD>Ownership of More than Five Percent on Behalf of Another Person:</TD></TR>                                                                                                                                           <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">See Item 4.</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 11pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 7.</TD><TD>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Not Applicable.</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 11pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 8.</TD><TD>Identification and Classification of Members of the Group</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Not Applicable.</P>
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<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 8  of 9 Pages</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: center; vertical-align: bottom">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 11pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 9.</TD><TD>Notice of Dissolution of Group</TD></TR>                                                                                                         <TR STYLE="vertical-align: top">
<TD>&nbsp;</TD><TD>&nbsp;</TD><TD>&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in">Not Applicable.</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 11pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 1in">Item 10.</TD><TD>Certification</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0in">By signing below I
certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and
are not held in connection with or as participant in any transaction having that purpose or effect.</P>


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<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>


<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 33%">CUSIP No. 09058V103</TD>
    <TD STYLE="width: 34%; text-align: center; vertical-align: bottom"><b>13G</b></TD>
    <TD STYLE="width: 33%; text-align: center; vertical-align: bottom">Page 9 of 9 Pages</TD></TR>
</TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">SIGNATURE</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0in">Date: January 11,
2019</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3in">&nbsp;</P>
<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">GREAT POINT PARTNERS, LLC&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 45%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>By:</TD>
    <TD STYLE="border-bottom: rgb(153,153,153) 1pt solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Dr. Jeffrey R. Jay, M.D.,</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>as senior managing member </TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: rgb(153,153,153) 1pt solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>DR. JEFFREY R. JAY, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: rgb(153,153,153) 1pt solid">/s/ Mr. David Kroin</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>MR. DAVID KROIN</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 24pt 3.5in">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0.25in; text-align: right"><U>Exhibit A</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 24pt; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13G</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 11pt; text-align: justify; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each
of them is individually eligible to use the Schedule 13G to which this Exhibit is attached, and such Schedule 13G is filed on behalf
of each of them; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 11pt; text-align: justify; text-indent: 0.5in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each
of them is responsible for the timely filing of such Schedule 13G and any amendments thereto, and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of
the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information
is inaccurate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">Date: January 11, 2019<A NAME="bmkPlaceHolder"></A></P>
<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">GREAT POINT PARTNERS, LLC</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 45%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>By:</TD>
    <TD STYLE="border-bottom: rgb(153,153,153) 1pt solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Dr. Jeffrey R. Jay, M.D.,</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>as senior managing member</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: rgb(153,153,153) 1pt solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>DR. JEFFREY R. JAY, M.D.</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: rgb(153,153,153) 1pt solid">/s/ Mr. David Kroin</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>MR. DAVID KROIN</TD></TR>
<TR STYLE="vertical-align: top; text-align: left">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3in"></P>










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