<SEC-DOCUMENT>0000899140-19-000618.txt : 20191119
<SEC-HEADER>0000899140-19-000618.hdr.sgml : 20191119
<ACCEPTANCE-DATETIME>20191119164247
ACCESSION NUMBER:		0000899140-19-000618
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20191119
DATE AS OF CHANGE:		20191119
GROUP MEMBERS:		CUBIST SYSTEMATIC STRATEGIES, LLC
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		191231797

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>p32052555a.htm
<DESCRIPTION>SCHEDULE 13G
<TEXT>
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    <div style="font-weight: bold;">240.13d-102 Schedule 13G - Information to be included in statements filed</div>
    <div style="font-weight: bold;">pursuant to 240.13d-1(b), (c), and (d) and amendments thereto</div>
    <div style="font-weight: bold;">filed pursuant to 240.13d-2.</div>
    <div style="background-color: #FFFFFF;">
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; color: #000000;">Securities and Exchange Commission, Washington, D.C. 20549</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">Schedule 13G</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">Under the Securities Exchange Act of 1934</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">(Amendment No._)*</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">(Name of Issuer)</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">BIOCRYST PHARMACEUTICALS, INC.</div>
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">(Title of Class of Securities)</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="color: #000000;">Common Stock, Par Value $0.01 Per Share</div>
      <div><br>
      </div>
      <div style="color: #000000;">(CUSIP Number)</div>
      <div><br>
      </div>
      <div style="color: #000000;">09058V103</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">&#160;(Date of Event Which Requires Filing of this Statement)</div>
    </div>
    <div>November 18, 2019</div>
    <div><br>
    </div>
    <div>Check the appropriate box to designate the rule pursuant to which this</div>
    <div>Schedule is filed:</div>
    <div style="background-color: #FFFFFF;">
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; color: #000000;">[&#160; ] Rule 13d-1(b)</div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; color: #000000;">[ x ] Rule 13d-1(c)</div>
      <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; color: #000000;">[&#160; ] Rule 13d-1(d)</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
      <div style="margin-top: 10pt; margin-bottom: 5pt;"><font style="color: #000000;">*The remainder of this cover page shall be filled out for a reporting person's<br>
          initial filing on this form with respect to the subject class of securities, and<br>
          for any subsequent amendment containing information which would alter the<br>
          disclosures provided in a prior cover page.<br>
          <br>
          <br>
          The information required in the remainder of this cover page shall not be<br>
          deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange<br>
          Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the<br>
          Act but shall be subject to all other provisions of the Act (however, see<br>
          the Notes).<br>
          </font>
        <div><br>
        </div>
        <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
          <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">1</font></div>
          <div style="page-break-after: always;" id="DSPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <br>
      </div>
      <div><br>
      </div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z8c93630629bc41a6b5eb7addd45f723d" style="font-family: 'Times New Roman', Times, serif; font-size: 12pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div style="text-align: center;">CUSIP No. 09058V103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(1) Names of reporting persons&#160; &#160; Point72 Asset Management, L.P.</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt;">(see instructions)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(3) SEC use only</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(4) Citizenship or place of organization&#160; Delaware</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 9,300,000 (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(8) Shared dispositive power&#160; &#160; &#160;&#160; 9,300,000 (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt;">9,300,000 (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div>(see instructions)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(11) Percent of class represented by amount in Row (9)&#160;&#160; 6.0% (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(12) Type of reporting person (see instructions)&#160; &#160;&#160; PN</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 10pt;"><br>
      <br>
    </div>
    <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" id="za45084796fc0474bb423a7d4bfec37f4" style="font-family: 'Times New Roman', Times, serif; font-size: 12pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div style="text-align: center;">CUSIP No. 09058V103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(1) Names of reporting persons&#160; &#160; Point72 Capital Advisors, Inc.</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt;">(see instructions)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(3) SEC use only</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(4) Citizenship or place of organization&#160; Delaware</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 9,300,000&#160; (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(8) Shared dispositive power&#160; &#160; &#160;&#160; 9,300,000 (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt;">9,300,000&#160; (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div>(see instructions)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(11) Percent of class represented by amount in Row (9)&#160;&#160; 6.0% (see Item 4)</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.73%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(12) Type of reporting person (see instructions)&#160; &#160;&#160; CO</div>
          </td>
          <td style="width: 6.27%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z14ebee0df03a4962bf16906bc6c4b11e" style="font-family: 'Times New Roman', Times, serif; font-size: 12pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div style="text-align: center;">CUSIP No. 09058V103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(1) Names of reporting persons&#160; &#160; Cubist Systematic Strategies, LLC</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt;">(see instructions)</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(3) SEC use only</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(4) Citizenship or place of organization&#160; Delaware</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 55,382 (see Item 4)</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(8) Shared dispositive power&#160; &#160; &#160;&#160; 55,382 (see Item 4)</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt;">55,382 (see Item 4)</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div>(see instructions)</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(11) Percent of class represented by amount in Row (9)&#160; &#160;&#160; &lt;0.1% (see Item 4)</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.92%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(12) Type of reporting person (see instructions)&#160; &#160;&#160; OO</div>
          </td>
          <td style="width: 6.08%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" id="z4fe9b385b33b456b9acee15e4329977e" style="font-family: 'Times New Roman', Times, serif; font-size: 12pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;" colspan="2">
            <div style="text-align: center;">CUSIP No. 09058V103</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(1) Names of reporting persons&#160; &#160; Steven A. Cohen</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt;">(see instructions)</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(3) SEC use only</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(4) Citizenship or place of organization&#160; United States</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 9,355,382 (see Item 4)</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(8) Shared dispositive power&#160; &#160; &#160;&#160; 9,355,382 (see Item 4)</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt;">9,355,382 (see Item 4)</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div>(see instructions)</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(11) Percent of class represented by amount in Row (9)&#160; 6.1% (see Item 4)</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.68%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div>(12) Type of reporting person (see instructions)&#160; &#160;&#160; IN</div>
          </td>
          <td style="width: 6.32%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
      <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">Item 1(a) Name of issuer:</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="margin-top: 10pt; margin-bottom: 12pt; color: #000000;">BIOCRYST PHARMACEUTICALS, INC.</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">Item 1(b) Address of issuer's principal executive offices:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">4505 Emperor Blvd., Suite&#160;200, Durham, North Carolina 27703</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">2(a) Name of person filing:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">This statement is filed by: (i) Point72 Asset Management, L.P. (&#8220;Point72 Asset<br>
        Management&#8221;) with respect to shares of common stock, par value $0.01 per<br>
        share (&#8220;Shares&#8221;), of the Issuer held by certain investment funds it manages;<br>
        (ii) Point72 Capital Advisors, Inc. (&#8220;Point72 Capital Advisors Inc.&#8221;) with<br>
        respect to Shares held by certain investment funds managed by Point72 Asset<br>
        Management; (iii) Cubist Systematic Strategies, LLC (&#8220;Cubist Systematic<br>
        Strategies&#8221;) with respect to Shares held by certain investment funds it<br>
        manages; and (iv) Steven A. Cohen (&#8220;Mr. Cohen&#8221;) with respect to Shares<br>
        beneficially owned by Point72 Asset Management, Point72 Capital Advisors Inc.,<br>
        and Cubist Systematic Strategies.<br>
        <br>
        <br>
        Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic<br>
        Strategies, and Mr. Cohen have entered into a Joint Filing Agreement, a copy of<br>
        which is filed with this Schedule 13G as Exhibit 99.1, pursuant to which they<br>
        have agreed to file this Schedule 13G jointly in accordance with the<br>
        provisions of Rule 13d-1(k) of the Act.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">2(b) Address or principal business office or, if none, residence:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">The address of the principal business office of (i) Point72 Asset Management,<br>
        Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road,<br>
        Stamford, CT 06902; and (ii) Cubist Systematic Strategies is 55 Hudson Yards, <br>
        New York, NY 10001.</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">2(c) Citizenship:</div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a <br>
        Delaware corporation. Cubist Systematic Strategies is a Delaware limited liability company. <br>
        Mr. Cohen is a United States citizen.</div>
      <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">2(d) Title of class of securities:</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="color: #000000;">Common Stock, Par Value $0.01 Per Share</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">2(e) CUSIP Number:</div>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="color: #000000;">09058V103</div>
      <div><br>
      </div>
    </div>
    <div style="font-style: italic;">Item 3.</div>
    <div><br>
    </div>
    <div>Not applicable</div>
    <div><br>
    </div>
    <div style="color: #000000;"><font style="font-style: italic;">Item 4. </font>Ownership</div>
    <div><br>
    </div>
    <div>As of the close of business on November 18, 2019:</div>
    <div><br>
    </div>
    <div style="color: #000000;">1. Point72 Asset Management, L.P.</div>
    <div><font style="color: #000000;">(a) Amount beneficially owned: </font>9,300,000</div>
    <div><font style="color: #000000;">(b) Percent of class: 6.0%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
    <div style="color: #000000;">(c) Number of shares as to which the person has:</div>
    <div style="color: #000000;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="color: #000000;">(ii) Shared power to vote or to direct the vote: </font>9,300,000</div>
    <div style="color: #000000;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div><font style="color: #000000;">(iv) Shared power to dispose or to direct the disposition of: </font>9,300,000</div>
    <div><br>
    </div>
    <div style="color: #000000;">2. Point72 Capital Advisors, Inc.</div>
    <div><font style="color: #000000;">(a) Amount beneficially owned: </font>9,300,000</div>
    <div><font style="color: #000000;">(b) Percent of class: 6.0%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
    <div style="color: #000000;">(c) Number of shares as to which the person has:</div>
    <div style="color: #000000;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="color: #000000;">(ii) Shared power to vote or to direct the vote: </font>9,300,000</div>
    <div style="color: #000000;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div><font style="color: #000000;">(iv) Shared power to dispose or to direct the disposition of: </font>9,300,000</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">7</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="color: #000000;">3. Cubist Systematic Strategies, LLC</div>
    <div><font style="color: #000000;">(a) Amount beneficially owned: </font>55,382</div>
    <div style="color: #000000;">(b) Percent of class: &lt;0.1%</div>
    <div style="color: #000000;">(c) Number of shares as to which the person has:</div>
    <div style="color: #000000;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="color: #000000;">(ii) Shared power to vote or to direct the vote: </font>55,382</div>
    <div style="color: #000000;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div><font style="color: #000000;">(iv) Shared power to dispose or to direct the disposition of: </font>55,382</div>
    <div><br>
    </div>
    <div style="color: #000000;">4. Steven A. Cohen</div>
    <div><font style="color: #000000;">(a) Amount beneficially owned: </font>9,355,382</div>
    <div style="color: #000000;">(b) Percent of class: 6.1%</div>
    <div style="color: #000000;">(c) Number of shares as to which the person has:</div>
    <div style="color: #000000;">(i) Sole power to vote or to direct the vote: 0</div>
    <div><font style="color: #000000;">(ii) Shared power to vote or to direct the vote: </font>9,355,382</div>
    <div style="color: #000000;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
    <div><font style="color: #000000;">(iv) Shared power to dispose or to direct the disposition of: </font>9,355,382</div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
      <div style="margin-right: 45pt; margin-top: 12pt; margin-bottom: 12pt;"><font style="color: #000000;">Point72
          Asset Management, Point72 Capital Advisors Inc., Cubist Systematic</font><br>
        <font style="color: #000000;">Strategies, and Mr. Cohen own directly no Shares. Pursuant to an investment</font><br>
        <font style="color: #000000;">management agreement, Point72 Asset Management maintains investment and voting</font><br>
        <font style="color: #000000;">power with respect to the securities held by certain investment funds it</font><br>
        <font style="color: #000000;">manages. Point72 Capital Advisors Inc. is the general partner of Point72 Asset</font><br>
        <font style="color: #000000;">Management. Pursuant to an investment management agreement, Cubist Systematic</font><br>
        <font style="color: #000000;">Strategies maintains investment and voting power with respect to the</font><br>
        <font style="color: #000000;">securities held by certain investment funds it manages. Mr. Cohen controls</font><br>
        <font style="color: #000000;">each of Point72 Asset Management, Point72 Capital Advisors Inc., and Cubist</font><br>
        <font style="color: #000000;">Systematic Strategies. By reason of the provisions of Rule 13d-3 of the</font><br>
        <font style="color: #000000;">Securities Exchange Act of 1934, as amended, each of (i) Point72 Asset</font><br>
        <font style="color: #000000;">Management, Point72 Capital Advisors Inc., and Mr. Cohen may be deemed to</font><br>
        <font style="color: #000000;">beneficially own </font>9,300,000 <font style="color: #000000;">Shares
          (constituting approximately </font>6.0<font style="color: #000000;">% of the</font><br>
        <font style="color: #000000;">Shares outstanding) and (ii) Cubist Systematic Strategies and Mr. Cohen may be</font><br>
        <font style="color: #000000;">deemed to beneficially own </font>55,382 <font style="color: #000000;">Shares
          (constituting &lt;0.1% of the Shares</font><br>
        <font style="color: #000000;">outstanding). Each of Point72 Asset Management, Point72 Capital Advisors Inc.,</font><br>
        <font style="color: #000000;">Cubist Systematic Strategies, and Mr. Cohen disclaims beneficial ownership</font><br>
        <font style="color: #000000;">of any of the securities covered by this statement.</font></div>
      <div><br>
      </div>
      <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
        <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">8</font></div>
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
    </div>
    <div><font style="font-style: italic;">Item 5. </font>Ownership of 5 Percent or Less of a Class.</div>
    <div><br>
    </div>
    <div>If this statement is being filed to report the fact that as of the date hereof</div>
    <div>the reporting person has ceased to be the beneficial owner of more than</div>
    <div>5 percent of the class of securities, check the following [].</div>
    <div><br>
    </div>
    <div><font style="font-style: italic;">Item 6.</font>&#160; Ownership of More than 5 Percent on Behalf of
      Another Person.</div>
    <div><br>
    </div>
    <div>Not applicable</div>
    <div><br>
    </div>
    <div><font style="font-style: italic;">Item 7.</font>&#160; Identification and Classification of the
      Subsidiary Which Acquired</div>
    <div>the Security Being Reporting on by the Parent Holding Company or Control</div>
    <div>Person.</div>
    <div><br>
    </div>
    <div style="background-color: #FFFFFF;">
      <div style="color: #000000;">Not applicable</div>
      <div><br>
      </div>
      <div style="color: #000000;"><font style="font-style: italic;">Item 8. </font>Identification and
        Classification of Members of the Group</div>
      <div><br>
      </div>
    </div>
    <div>Not applicable</div>
    <div><br>
    </div>
    <div><font style="font-style: italic;">Item 9.</font>&#160; Notice of Dissolution of Group.</div>
    <div><br>
    </div>
    <div>Not applicable</div>
    <div><br>
    </div>
    <div style="color: #000000;"><font style="font-style: italic;">Item 10. </font>Certifications</div>
    <div><br>
    </div>
    <div style="color: #000000;"><font style="background-color: #FFFFFF;">By signing below I certify that, to the best of my knowledge and belief,</font></div>
    <div style="color: #000000;"><font style="background-color: #FFFFFF;">the securities referred to above were not acquired and are not held for the purpose</font></div>
    <div style="color: #000000;"><font style="background-color: #FFFFFF;">of or with the effect of changing or influencing the control of the issuer of</font></div>
    <div style="color: #000000;"><font style="background-color: #FFFFFF;">the securities and were not acquired and are not held in connection with or</font></div>
    <div style="color: #000000;"><font style="background-color: #FFFFFF;">as a participant in any transaction having that purpose or effect.</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 12pt; margin-bottom: 12pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="font-size: 10pt; font-weight: normal; font-style: normal;" id="DSPFPageNumber">9</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div><font style="font-style: italic;">Signature.</font>&#160; After reasonable inquiry and to the best
      of my knowledge and belief,</div>
    <div>I certify that the information set forth in this statement is true, complete</div>
    <div>and correct.</div>
    <div style="background-color: #FFFFFF;">
      <div><br>
      </div>
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">Dated: <u>November 19,
            2019</u></div>
      <div><br>
      </div>
    </div>
    <div style="margin-bottom: 10pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt;">CUBIST SYSTEMATIC STRATEGIES, LLC</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt;">STEVEN A. COHEN</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><font style="background-color: #FFFFFF;"> <br>
      </font></div>
    <div><font style="background-color: #FFFFFF;"> <br>
      </font></div>
    <div><font style="background-color: #FFFFFF;"> <br>
      </font></div>
    <div><font style="background-color: #FFFFFF;"> <br>
      </font></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>p32052555b.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
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  <head>
    <title></title>
    <!-- Licensed to: Willkie Farr Gallagher
         Document created using EDGARfilings PROfile 6.3.0.0
         Copyright 1995 - 2019 Broadridge -->
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  <div>
    <div style="color: #000000;">Exhibit 99.1</div>
    <div style="text-align: center; color: #000000;">JOINT FILING AGREEMENT</div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="margin-bottom: 10pt; color: #000000;">The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned
      in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessity of
      filing additional joint filing agreements.&#160; <br>
    </div>
  </div>
  <div>
    <div style="background-color: #FFFFFF;">
      <div style="margin-top: 12pt; margin-bottom: 12pt; color: #000000;">Dated: <u>November 19,
            2019</u></div>
      <div><br>
      </div>
    </div>
    <div style="margin-bottom: 10pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt;">CUBIST SYSTEMATIC STRATEGIES, LLC</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt;">STEVEN A. COHEN</div>
    <div style="margin-bottom: 10pt; color: #000000;"><font style="background-color: #FFFFFF;">By: </font><font style="background-color: #FFFFFF;"><u>/s/ Jason M. Colombo</u></font></div>
    <div><font style="background-color: #FFFFFF;">Name: Jason M. Colombo</font></div>
    <div><font style="background-color: #FFFFFF;">Title: Authorized Person</font></div>
  </div>
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</DOCUMENT>
</SEC-DOCUMENT>
