    <SEC-DOCUMENT>0001171843-19-002459-index.html : 20190417
    <SEC-HEADER>0001171843-19-002459.hdr.sgml : 20190417
    <ACCEPTANCE-DATETIME>20190417103515
    ACCESSION NUMBER:		0001171843-19-002459
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		5
    FILED AS OF DATE:		20190417
    DATE AS OF CHANGE:		20190417
    EFFECTIVENESS DATE:		20190417

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000882796
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				621413174
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-23186
    		FILM NUMBER:		19752428

    	BUSINESS ADDRESS:
    		STREET 1:		4505 EMPEROR BOULEVARD
    		STREET 2:		SUITE 200
    		CITY:			DURHAM
    		STATE:			NC
    		ZIP:			27703
    		BUSINESS PHONE:		919-859-1302

    	MAIL ADDRESS:
    		STREET 1:		4505 EMPEROR BOULEVARD
    		STREET 2:		SUITE 200
    		CITY:			DURHAM
    		STATE:			NC
    		ZIP:			27703
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>defa14a_041719.htm
    <DESCRIPTION>DEFINITIVE ADDITIONAL MATERIALS
    <TEXT>
    Document 1 - file: defa14a_041719.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>card_1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: card_1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>card_2.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: card_2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>card_3.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: card_3.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>card_4.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: card_4.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>