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v3.20.1

Note 1 - Significant Accounting Policies and Concentrations of Risk - Summary of Revenues (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Revenues | $ 39,725 | $ 1,775 | $ 1,448 | $ 5,887 | $ 2,729 | $ 1,454 | $ 12,494 | $ 3,976 | $ 48,835 | $ 20,653 | $ 25,186
Torii Pharmaceutical Co. [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 20,101 |  |
Product [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 17,533 |  | 1,501
Royalty [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 6,303 | 6,101 | 10,543
Collaborative and Other Research and Development [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 24,999 | 14,552 | 13,142
Collaborative and Other Research and Development [Member] | US Department of Health and Human Services [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 4,898 | 2,552 | 4,608
Collaborative and Other Research and Development [Member] | Torii Pharmaceutical Co. [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  | 20,101 |  |
Collaborative and Other Research and Development [Member] | Shionogi and Co. Ltd [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  |  | 1,184
Collaborative and Other Research and Development [Member] | Seqirus UK Limited [Member] |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  |  |  | $ 12,000 | $ 7,350

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