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Note 8 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2019 | Dec. 31, 2018
--- | --- | ---
Net federal and state operating losses | $ 155,190 | $ 137,234
Research and development credits | 63,275 | 59,509
Stock-based compensation | 9,786 | 7,108
Leasing obligations | 1,070 |
Other | 3,801 | 5,258
Total deferred tax assets | 233,122 | 209,109
Fixed assets | (114) | (418)
Right of use asset | (803) |
Foreign currency derivative |  | (231)
Total deferred tax liabilities | (917) | (649)
Valuation allowance | (232,205) | (208,460)
Net deferred tax assets |  |

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