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v3.20.1

Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables) | 12 Months Ended
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Dec. 31, 2019
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | December 31, 2019
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 10,488 |  |  | $ | 50 |  |  | $ | 23 |  |  | $ | - |  |  | $ | 10,561 |
Corporate debt securities |  |  | 9,742 |  |  |  | 59 |  |  |  | 10 |  |  |  | (1 | ) |  |  | 9,810 |
Certificates of deposit |  |  | 1,669 |  |  |  | 7 |  |  |  | 7 |  |  |  | - |  |  |  | 1,683 |
Total investments |  | $ | 21,899 |  |  | $ | 116 |  |  | $ | 40 |  |  | $ | (1 | ) |  | $ | 22,054 |
|  | December 31, 2018
|  | Amortized Cost |  | Accrued Interest |  | Gross Unrealized Gains |  | Gross Unrealized Losses |  | Estimated Fair Value
Obligations of U.S. Government and its agencies |  | $ | 50,613 |  |  | $ | 176 |  |  | $ | 15 |  |  | $ | (131 | ) |  | $ | 50,673 |
Corporate debt securities |  |  | 45,793 |  |  |  | 254 |  |  |  | 4 |  |  |  | (171 | ) |  |  | 45,880 |
Certificates of deposit |  |  | 3,559 |  |  |  | 14 |  |  |  | - |  |  |  | (14 | ) |  |  | 3,559 |
Total investments |  | $ | 99,965 |  |  | $ | 444 |  |  | $ | 19 |  |  | $ | (316 | ) |  | $ | 100,112 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | 2019 |  | 2018
Maturing in one year or less |  | $ | 22,054 |  |  | $ | 77,736 |
Maturing after one year through two years |  |  | - |  |  |  | 22,376 |
Total investments |  | $ | 22,054 |  |  | $ | 100,112 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | December 31, 2019
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | 1,353 |  |  | $ | 15,023 |  |  | $ | 16,376 |
Shionogi & Co. Ltd. |  |  | 1,336 |  |  |  | 4 |  |  |  | 1,340 |
Green Cross Corporation |  |  | 2,924 |  |  |  | 8 |  |  |  | 2,932 |
Mundipharma International Holdings Limited |  |  | 56 |  |  |  | - |  |  |  | 56 |
Seqirus UK Limited |  |  | 1,091 |  |  |  | 351 |  |  |  | 1,442 |
Total receivables |  | $ | 6,760 |  |  | $ | 15,386 |  |  | $ | 22,146 |
|  | December 31, 2018
|  | Billed |  | Unbilled |  | Total
U.S. Department of Health and Human Services |  | $ | - |  |  | $ | 1,525 |  |  | $ | 1,525 |
Shionogi & Co. Ltd. |  |  | 854 |  |  |  | - |  |  |  | 854 |
Green Cross Corporation |  |  | 876 |  |  |  | 28 |  |  |  | 904 |
Mundipharma International Holdings Limited |  |  | 44 |  |  |  | - |  |  |  | 44 |
Seqirus UK Limited |  |  | 940 |  |  |  | 26 |  |  |  | 966 |
Total receivables |  | $ | 2,714 |  |  | $ | 1,579 |  |  | $ | 4,293 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31,
|  | 2019 |  | 2018
Compensation and benefits |  | $ | 6,190 |  |  | $ | 4,659 |
Development costs |  |  | 11,302 |  |  |  | 7,564 |
Inventory |  |  | 29 |  |  |  | 1,649 |
Professional fees |  |  | 326 |  |  |  | 118 |
Duties and taxes |  |  | 67 |  |  |  | 51 |
Other |  |  | 3,451 |  |  |  | 1,850 |
Total accrued expenses |  | $ | 21,365 |  |  | $ | 15,891 |
Disaggregation of Revenue [Table Text Block] |
|  | 2019 |  | 2018 |  | 2017
Product sales, net |  | $ | 17,533 |  |  | $ | - |  |  | $ | 1,501 |
Royalty revenue |  |  | 6,303 |  |  |  | 6,101 |  |  |  | 10,543 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 4,898 |  |  |  | 2,552 |  |  |  | 4,608 |
Torii Pharmaceutical Co., Ltd. |  |  | 20,101 |  |  |  | - |  |  |  | - |
Shionogi & Co. Ltd. |  |  | - |  |  |  | - |  |  |  | 1,184 |
Seqirus UK Limited |  |  | - |  |  |  | 12,000 |  |  |  | 7,350 |
Total collaborative and other research and development revenues |  |  | 24,999 |  |  |  | 14,552 |  |  |  | 13,142 |
Total revenues |  | $ | 48,835 |  |  | $ | 20,653 |  |  | $ | 25,186 |

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