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Note 6 - Stockholders' Equity
12 Months Ended
Dec. 31, 2019
Notes to Financial Statements  
Stockholders' Equity Note Disclosure [Text Block]
Note 
6
 — Stockholders’ Equity
 
Sales of Common Stock
 
On
November 8, 2017,
the Company filed a
$200,000
shelf registration statement on Form S-
3
with the SEC. This shelf registration statement became effective on
December 12, 2017
and allows the Company to sell securities, including common stock, preferred stock, depository shares, stock purchase contracts, warrants and units, from time to time at prices and on terms to be determined at the time of sale.
 
On
August 6, 2018,
the Company completed an underwritten public offering of
10,455
shares of its common stock, offered at a price to the public of
$5.50
per share, including shares issued pursuant to the underwriters’
30
-day option to purchase additional shares, which was exercised in full. The net proceeds from this offering were approximately
$53,400
after deducting underwriting discounts and commissions and estimated offering expenses. 
 
On
November 18, 2019,
the Company completed an underwritten public offering of
43,621
shares of its common stock, offered at a price to the public of
$1.45
per share, including shares issued pursuant to the underwriters’
30
-day option to purchase additional shares, which was exercised in full. The net proceeds from this offering were approximately
$53,500
after deducting underwriting discounts and commissions and estimated offering expenses. 
 
On
November 21, 2019,
the Company completed an offering of pre-funded warrants to purchase up to
11,765
shares of its common stock at a price of
$1.69
per warrant. Each pre-funded warrant is exercisable at the holder’s option into
1
share of common stock at an exercise price of
$0.01
per share. The net proceeds from this offering were
$19,882,
excluding any proceeds the Company
may
receive upon the subsequent exercise of the pre-funded warrants. All warrants issued in this offering remain outstanding at
December 31, 2019.