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Note 8 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2019

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

		2019				2018				2017
Income tax benefit at federal statutory rate (21% for 2019, 2018 and 2017)		$	(22,868	)		$	(21,263	)		$	(23,024	)
State and local income taxes net of federal tax benefit			(1,591	)			(2,547	)			(1,611	)
Permanent items			691				503				910
Rate change			625				(29	)			71,155
Expiration of attribute carryforwards			3,976				2,183				918
Effect of ASU 2016-09			-				-				(5,949	)
Research and development tax credits			(4,938	)			(4,905	)			(1,977	)
Orphan drug credit			-				-				564
Other			281				18				1,639
Change in valuation allowance			23,824				26,040				(42,625	)
Income tax expense		$	-			$	-			$	-

Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]

		2019				2018
Balance at January 1,		$	5,976			$	4,750
Additions to current period tax positions			1,234				1,226
Additions to prior period tax positions			-				-
Reductions to prior period tax provisions			-				-
Balance at December 31,		$	7,210			$	5,976

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

		2019				2018
Deferred tax assets:
Net federal and state operating losses		$	155,190			$	137,234
Research and development credits			63,275				59,509
Stock-based compensation			9,786				7,108
Leasing obligations			1,070				-
Other			3,801				5,258
Total deferred tax assets			233,122				209,109
Deferred tax liabilities:
Fixed assets			(114	)			(418	)
Right of use asset			(803	)			-
Foreign currency derivative			-				(231	)
Total deferred tax liabilities			(917	)			(649	)
Valuation allowance			(232,205	)			(208,460	)
Net deferred tax assets		$	-			$	-

X

- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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