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Consolidated Statements of Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenues:
Revenues	$ 48,835	$ 20,653	$ 25,186
Expenses
Cost of products sold	3,726		1,142
Research and development	107,068	84,888	66,962
Selling, general and administrative	37,121	29,514	13,933
Royalty	375	471	560
Total operating expenses	148,290	114,873	82,597
Loss from operations	(99,455)	(94,220)	(57,411)
Interest and other income	1,933	2,252	1,015
Interest expense	(11,892)	(9,176)	(8,565)
Gain (loss) on foreign currency derivative	517	(108)	(821)
Net loss	(108,897)	(101,252)	(65,782)
Unrealized gain (loss) on available for sale investments	336	(54)	(231)
Net comprehensive loss	$ (108,561)	$ (101,306)	$ (66,013)
Basic and diluted net loss per common share (in dollars per share)	$ (0.94)	$ (0.98)	$ (0.78)
Weighted average shares outstanding (in shares)	115,600	103,185	84,451
Product [Member]
Revenues:
Revenues	$ 17,533		$ 1,501
Royalty [Member]
Revenues:
Revenues	6,303	6,101	10,543
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 24,999	$ 14,552	$ 13,142

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Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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