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Note 8 - Income Taxes (Details Textual) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2017
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Mar. 31, 2017
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent   21.00% 21.00% 35.00%  
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability $ 73,474        
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount   $ 23,824 $ 26,040 $ (42,625)  
Open Tax Year   2016 2017 2018 2019      
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total $ 0 $ 0 $ 0 $ 0  
Research Tax Credit Carryforward [Member]          
Tax Credit Carryforward, Amount   70,485      
Domestic Tax Authority [Member]          
Operating Loss Carryforwards, Total   653,524      
State and Local Jurisdiction [Member]          
Operating Loss Carryforwards, Total   $ 509,639      
Accounting Standards Update 2016-09 [Member]          
Deferred Tax Assets, Operating Loss Carryforwards, Total         $ 5,949