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Note 8 - Income Taxes - Differences Between the Company's Effective Tax Rate and the Statutory Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Income tax benefit at federal statutory rate (21% for 2019, 2018 and 2017)	$ (22,868)	$ (21,263)	$ (23,024)
State and local income taxes net of federal tax benefit	(1,591)	(2,547)	(1,611)
Permanent items	691	503	910
Rate change	625	(29)	71,155
Expiration of attribute carryforwards	3,976	2,183	918
Effect of ASU 2016-09			(5,949)
Research and development tax credits	(4,938)	(4,905)	(1,977)
Orphan drug credit			564
Other	281	18	1,639
Change in valuation allowance	23,824	26,040	(42,625)
Income tax expense	$ 0	$ 0	$ 0

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