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Note 8 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2019	Dec. 31, 2018
Net federal and state operating losses	$ 155,190	$ 137,234
Research and development credits	63,275	59,509
Stock-based compensation	9,786	7,108
Leasing obligations	1,070
Other	3,801	5,258
Total deferred tax assets	233,122	209,109
Fixed assets	(114)	(418)
Right of use asset	(803)
Foreign currency derivative		(231)
Total deferred tax liabilities	(917)	(649)
Valuation allowance	(232,205)	(208,460)
Net deferred tax assets

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