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Note 1 - Significant Accounting Policies (Details Textual) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019	Dec. 31, 2019	Sep. 23, 2016	Mar. 09, 2011
Long-term Line of Credit, Total	$ 36,513		$ 41,289
Restricted Cash and Cash Equivalents, Current, Total	1,559		1,551
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax	0	$ 0
Interest Expense, Debt, Total	3,047	2,726
Amortization of Debt Issuance Costs	$ 341	$ 255
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares)	12,196	3,406
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative	$ 20
Derivative, Gain on Derivative		$ 406
Currency Hedge Agreement [Member]
Collateral Already Posted, Aggregate Fair Value	$ 0		0
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)	3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life (Year)	5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life (Year)	7 years
Maximum [Member]
Maturity Period of High Quality Marketable Securities (Year)	3 years
Average Maturity Period of High Quality Marketable Securities (Month)	1 year 180 days
Maturity Period of Short Term Investment (Month)	1 year
Average Maturity for Portfolio Investments (Month)	1 year 180 days
Minimum [Member]
Long-term Investment Maturity, Minimum (Month)	1 year
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current, Total	$ 134		134
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents, Current, Total	1,425		$ 1,417
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]
Long-term Line of Credit, Total	$ 50,000			$ 23,000
JPR Royalty Sub LLC [Member]
Revenue Recognition Royalty and Milestone Revenue Recognized					$ 30,000

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