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Note 3 - Collaborative and Other Research and Development Contracts 1 (Details Textual) - USD ($) $ in Thousands						1 Months Ended			3 Months Ended		12 Months Ended		55 Months Ended	60 Months Ended
	Mar. 04, 2020	Nov. 05, 2019	Sep. 06, 2018	Jun. 16, 2015	Feb. 28, 2006	Sep. 30, 2013	Jun. 30, 2006	Jun. 30, 2000	Mar. 31, 2020	Mar. 31, 2019	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2019	Mar. 31, 2020	Mar. 31, 2015	Nov. 11, 2011
Revenue from Contract with Customer, Including Assessed Tax									$ 4,823	$ 5,887
Arbitration Proceedings of SUL Agreement [Member]
Litigation Settlement, Amount Awarded from Other Party	$ 5,000,000
Arbitration Proceedings of SUL Agreement [Member] | Other Income [Member]
Gain (Loss) Related to Litigation Settlement, Total									6,138
Arbitration Proceedings of SUL Agreement [Member] | Selling, General and Administrative Expenses [Member]
Legal Fees									4,668
US Department of Health and Human Services [Member]
Collaborative Agreement Contract Value			$ 34,660
Contract Term (Year)			5 years
Proceeds from Collaborators												$ 13,864
US Department of Health and Human Services [Member] | Forecast [Member]
Proceeds from Collaborators											$ 6,932
Torii Pharmaceutical Co. [Member]
Upfront Payments Receivable Amount		$ 22,000
Potential Milestone Payments Receivable if Regulatory Approval Before December 31, 2020		20,000
Potential Milestone Payments Receivable if Regulatory Approval Before December 31, 2021		$ 15,000
Maximum Customary Reduction on Royalty Rate		50.00%
Royalty Payments Receivable, Expiration Term From First Commercial (Year)		10 years
Revenue from Contract with Customer, Including Assessed Tax												20,101
Torii Pharmaceutical Co. [Member] | License [Member]
Revenue from Contract with Customer, Including Assessed Tax												19,344
Torii Pharmaceutical Co. [Member] | Service [Member]
Revenue from Contract with Customer, Including Assessed Tax												$ 757
Torii Pharmaceutical Co. [Member] | Minimum [Member]
Royalty Rate if Maintains Sakigake Designation		20.00%
Royalty Rate, Otherwise		15.00%
Torii Pharmaceutical Co. [Member] | Maximum [Member]
Royalty Rate if Maintains Sakigake Designation		40.00%
Royalty Rate, Otherwise		35.00%
CSL Limited [Member
Proceeds from License Fees Received				$ 33,740
Milestone Payment Received													$ 12,000
Royalty Term (Year)				10 years
Base Contract [Member]
Government Contract Receivable															$ 16,265
Additional Development Options [Member]
Government Contract Receivable															22,855
ASPRBARDA Contract [Member]
Government Contract Receivable															$ 39,120
Proceeds from awards for Research and Development Contracts														$ 20,574
Green Cross Corporation [Member]
Proceeds from License Fees Received							$ 250
Mundipharma [Member]
Upfront Payments Receivable Amount					$ 10,000
Potential Milestone Payments Receivable																$ 15,000
AECOM and IRL [Member]
Milestone Payment Minimum								$ 1,400
Milestone Payment Maximum								4,000
Annual License Fee Minimum								150
Annual License Fee Maximum								$ 500
Advance Notice Period for Termination of Agreement (Day)								60 days
National Institute of Allergy and Infectious Diseases [Member]
Collaborative Agreement Contract Value						$ 5,000
Expected Receivable From Awards for Research and Development Contracts									$ 43,035
UAB [Member]
Period of Agreement (Year)									25 years
Renewable Period of Agreement (Year)									5 years

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