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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues:
Revenues	$ 4,823	$ 5,887
Expenses
Cost of product sales		1,399
Research and development	29,867	27,493
Selling, general and administrative	15,865	6,238
Royalty	69	87
Total operating expenses	45,801	35,217
Loss from operations	(40,978)	(29,330)
Interest and other income	6,446	596
Interest expense	(3,047)	(2,726)
(Loss) gain on foreign currency derivative	(20)	406
Net loss	(37,599)	(31,054)
Unrealized (loss) gain on available for sale investments	(25)	208
Net comprehensive loss	$ (37,624)	$ (30,846)
Basic and diluted net loss per common share (in dollars per share)	$ (0.24)	$ (0.28)
Weighted average shares outstanding (in shares)	154,156	110,167
Product [Member]
Revenues:
Revenues	$ 218	$ 1,679
Royalty [Member]
Revenues:
Revenues	1,945	2,322
Collaborative and Other Research and Development [Member]
Revenues:
Revenues	$ 2,660	$ 1,886

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