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Note 1 - Significant Accounting Policies (Details Textual) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2019 | Sep. 23, 2016 | Mar. 09, 2011
Long-term Line of Credit, Total | $ 31,715 |  | $ 31,715 |  | $ 41,289 |  |
Restricted Cash and Cash Equivalents, Current, Total | 2,188 |  | 2,188 |  | 1,551 |  |
Inventory, Raw Materials, Net of Reserves | 1,723 |  | 1,723 |  |  |  |
Inventory, Work in Process, Net of Reserves | 3,510 |  | 3,510 |  |  |  |
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax |  |  | 1 | $ 0 |  |  |
Interest Expense, Debt, Total | 2,918 | $ 3,035 | 5,965 | 5,761 |  |  |
Amortization of Debt Issuance Costs | $ 341 | $ 341 | $ 681 | $ 596 |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | 14,007 | 1,927 | 12,963,000 | 2,528,000 |  |  |
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |  |  |  |
Derivative, Loss on Derivative |  |  | $ 590 | $ 646 |  |  |
Derivative, Gain on Derivative |  |  | 632 | $ 830 |  |  |
Currency Hedge Agreement [Member] |  |  |  |  |  |  |
Collateral Already Posted, Aggregate Fair Value | $ 0 |  | $ 0 |  | 0 |  |
Computer Equipment [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  |  | 3 years |  |  |  |
Laboratory Equipment, Office Equipment and Software [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  |  | 5 years |  |  |  |
Furniture and Fixtures [Member] |  |  |  |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  |  | 7 years |  |  |  |
Maximum [Member] |  |  |  |  |  |  |
Maturity Period of High Quality Marketable Securities (Year) |  |  | 3 years |  |  |  |
Average Maturity Period of High Quality Marketable Securities (Month) |  |  | 18 months |  |  |  |
Maturity Period of Short Term Investment (Month) |  |  | 12 months |  |  |  |
Average Maturity for Portfolio Investments (Month) |  |  | 18 months |  |  |  |
Minimum [Member] |  |  |  |  |  |  |
Long-term Investment Maturity, Minimum (Month) |  |  | 12 months |  |  |  |
Royalty Receivable [Member] |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 766 |  | $ 766 |  | 134 |  |
Collateral for Credit [Member] |  |  |  |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 1,422 |  | 1,422 |  | $ 1,417 |  |
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member] |  |  |  |  |  |  |
Long-term Line of Credit, Total | $ 50,000 |  | $ 50,000 |  |  | $ 23,000 |
JPR Royalty Sub LLC [Member] |  |  |  |  |  |  |
Revenue Recognition Royalty and Milestone Revenue Recognized |  |  |  |  |  |  | $ 30,000

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